Zonegran and Ritalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Ritalin (methylphenidate hydrochloride). Common drug interactions include kidney infection among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Ritalin. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

On Jul, 12, 2026

89 people who take Zonegran and Ritalin together, and have interactions are studied.

What are the common drug interactions of Zonegran and Ritalin, by gender? *:

female:

Kidney infection
Laceration (tearing of soft body tissue)
Ligament sprain (ligament stretched)
Loss of consciousness
Lymphocyte count decreased
Micturition urgency (urgency to pass the urine)
Urinary tract infection
Suicidal ideation
Type 2 diabetes mellitus
Dry eye (lack of adequate tears)

male:

Fall
Alcohol poisoning
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glossitis (infection of tongue with soreness)
Head injury
Loss of consciousness
Paraplegia (paralysis of the legs and lower body)
Renal failure (kidney dysfunction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Speech disorder

What are the common drug interactions of Zonegran and Ritalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abasia (inability to walk)
Head lag (weak head and neck control)
Muscular weakness (muscle weakness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Speech disorder
Urinary incontinence (inability to control the flow of urine and involuntary urination)

10-19:

n/a

20-29:

n/a

30-39:

Alcohol poisoning
Arthralgia (joint pain)
Back injury
Back pain
Cervical vertebral fracture
Concussion (short loss of normal brain function in response to a head injury)
Confusional state
Cough
Drug specific antibody present
Dysphagia (a condition in which swallowing is difficult or painful)

40-49:

Mood altered (changes in mood)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Muscular weakness (muscle weakness)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Paranasal cyst (cyst near the nose)
Suicidal ideation
Syncope (loss of consciousness with an inability to maintain postural tone)
Temperature intolerance (inability to go in temperature)
Therapeutic response unexpected
Type 2 diabetes mellitus

50-59:

Nephrolithiasis (calculi in the kidneys)
Chronic kidney disease
Hospitalisation
Hypokalaemia (low potassium)
Infection
Hypersensitivity
Hypotension (abnormally low blood pressure)
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory rate decreased (less breathing rate/min)
Unresponsive to stimuli

60+:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lower respiratory tract infection
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Neck pain
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Pain in extremity
Peripheral swelling

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 56 people, 62.92%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 39 people, 43.82%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 11.24%
Pain: 9 people, 10.11%
Migraine (headache): 9 people, 10.11%
Stress And Anxiety: 7 people, 7.87%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.74%
High Blood Pressure: 5 people, 5.62%
Drowsiness: 5 people, 5.62%

* Approximation only. Some reports may have incomplete information.

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