Zonegran and Soma drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Soma (carisoprodol). Common drug interactions include injection site mass among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Soma. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Soma?

Soma has active ingredients of carisoprodol. It is often used in muscle spasms. eHealthMe is studying from 17,137 Soma users. Check the latest studies of Soma.

On Jul, 13, 2026

32 people who take Zonegran and Soma together, and have interactions are studied.

What are the common drug interactions of Zonegran and Soma, by gender? *:

female:

Injection site mass
Insomnia (sleeplessness)
Intervertebral disc protrusion (spinal disc protrusion)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Multi-organ failure (multisystem organ failure)
Nasopharyngitis (inflammation of the nasopharynx)
Neuropathy (damage to nerves)
Nightmare (unpleasant dream)
Oral discomfort (pain or irritation in mouth)
Overdose

male:

Weight increased
Tremor (trembling or shaking movements in one or more parts of your body)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Diabetes mellitus inadequate control
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Hyperglycaemia (high blood sugar)
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Asthenia (weakness)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Zonegran and Soma, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Vomiting
Weight decreased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)
Memory impairment
Nausea (feeling of having an urge to vomit)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Surgery
Abdominal pain upper

40-49:

Asthenia (weakness)
Anxiety
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Cardiac disorder
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Weight increased

50-59:

Acne (skin problems that cause pimples)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site haemorrhage (bleeding from injection site)
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Drug level decreased
Skin burning sensation
Arthralgia (joint pain)
Croup infectious (a loud cough that resembles the barking of a seal and difficulty breathing can transfer to other)

60+:

Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Sciatic nerve injury
Subdural haematoma (blood collects between the skull and the surface of the brain)
Tooth abscess (pus formation in tooth)
Tremor (trembling or shaking movements in one or more parts of your body)
Constipation
Facial bones fracture (bone fracture of face)
Fall

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 28.12%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 18.75%
Pain: 5 people, 15.62%
Back Pain: 4 people, 12.50%
Osteoporosis (bones weak and more likely to break): 4 people, 12.50%
Insomnia (sleeplessness): 3 people, 9.38%
Barrett's Oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach): 3 people, 9.38%
Diarrhea: 3 people, 9.38%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 3 people, 9.38%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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