Zonisamide and Cipro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Cipro (ciprofloxacin hydrochloride). Common drug interactions include diverticulum among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Cipro. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Cipro?

Cipro has active ingredients of ciprofloxacin hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 35,126 Cipro users. Check the latest studies of Cipro.

On Jul, 12, 2026

23 people who take Zonisamide and Cipro together, and have interactions are studied.

What are the common drug interactions of Zonisamide and Cipro, by gender? *:

female:

Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Gastrointestinal ulcer
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Dry eye (lack of adequate tears)
Migraine with aura (headache with vision weakness)
Type 2 diabetes mellitus
Haemorrhage (bleeding)
Dementia (madness)
Duodenal ulcer
Abdominal discomfort

male:

Abdominal distension
Abdominal pain
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Gastritis (inflammation of stomach)
Hypertension (high blood pressure)
Injection site bruising
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Muscle spasms (muscle contraction)

What are the common drug interactions of Zonisamide and Cipro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal distension
Abdominal pain
Abdominal pain lower
Asthenia (weakness)
Constipation
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Duodenitis (inflammation of the duodenum)
Dyspnoea (difficult or laboured respiration)
Enterovesical fistula

10-19:

Oxygen saturation decreased
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Serratia test positive
Tracheitis (an inflammation of the trachea)

20-29:

Abdominal discomfort
Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Faeces discoloured
Hypokalaemia (low potassium)

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)

40-49:

Aphthous ulcer (mouth ulcer)
Lymphocyte stimulation test positive
Uveitis (inflammation of the uvea)
Anal fissure

50-59:

Chronic kidney disease
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Cardiomegaly (increased size of heart than normal)
Dementia (madness)
Drug hypersensitivity
Dry eye (lack of adequate tears)
Haemorrhage (bleeding)
Migraine with aura (headache with vision weakness)
Type 2 diabetes mellitus

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 39.13%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 39.13%
Stress And Anxiety: 4 people, 17.39%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 17.39%
Asthma: 3 people, 13.04%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.70%
Pain: 2 people, 8.70%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 8.70%
Mood Swings (an extreme or rapid change in mood): 2 people, 8.70%
Joint Pain: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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