Zonisamide and Digoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Digoxin (digoxin). Common drug interactions include headache among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Digoxin. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

On Jul, 09, 2026

33 people who take Zonisamide and Digoxin together, and have interactions are studied.

Zonisamide and Digoxin drug interactions.

What are the common drug interactions of Zonisamide and Digoxin, by gender? *:

female:

Headache (pain in head)
Hypersomnia (excessive daytime sleepiness (eds))
Hypotension (abnormally low blood pressure)
Injection site pain
Lethargy (tiredness)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Neuropathy peripheral (surface nerve damage)
Oedema (fluid collection in tissue)
Pleural effusion (water on the lungs)
Pneumonia

male:

Anxiety
Asthma
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Urticaria (rash of round, red welts on the skin that itch intensely)
Partial seizures (seizures which affect only a part of the brain at onset)
Viral cardiomyopathy (weakness in the muscle of the heart due to viral infection)
Cardiac failure
Choking sensation (feeling of obstruction in respiratory system)
Depression
Lung disorder (lung disease)

What are the common drug interactions of Zonisamide and Digoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Traumatic lung injury
Tricuspid valve incompetence (inefficient heart valve)
Viral myocarditis (inflammation of heart muscle caused by viral infection)
Anxiety
Asthma
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Hyperhidrosis (abnormally increased sweating)
Lower respiratory tract infection
Muscular weakness (muscle weakness)
Asthenia (weakness)

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Oedema (fluid collection in tissue)

60+:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
International normalised ratio increased
Peripheral swelling
Pyrexia (fever)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Bacterial toxaemia (blood contains bacterial toxins)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood creatinine increased
Blood lactic acid increased

What are the existing conditions these people have? *

High Blood Cholesterol: 4 people, 12.12%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 12.12%
Multiple Myeloma (cancer of the plasma cells): 3 people, 9.09%
Thyroid Diseases: 2 people, 6.06%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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