Zonisamide and Estradiol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Estradiol (estradiol). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Estradiol. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

On Jul, 11, 2026

42 people who take Zonisamide and Estradiol together, and have interactions are studied.

Zonisamide and Estradiol drug interactions.

What are the common drug interactions of Zonisamide and Estradiol, by gender? *:

female:

Drug ineffective
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Dementia (madness)
Fatigue (feeling of tiredness)
Injury
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Blood cholesterol increased
Blood iron decreased

male:

n/a

What are the common drug interactions of Zonisamide and Estradiol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Sinusitis (inflammation of sinus)

30-39:

Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Blood cholesterol increased
Blood iron decreased
Blood potassium decreased
Dyspnoea (difficult or laboured respiration)
Electrocardiogram st segment depression
Fatigue (feeling of tiredness)
Feeling hot
Fibromyalgia (a long-term condition which causes pain all over the body)

40-49:

Injury
Limb injury
Skin infection
Depression
Gamma-glutamyltransferase increased
Suicidal ideation
Calculus urinary (stone in urinary system)
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Intervertebral disc displacement

50-59:

Cardiomegaly (increased size of heart than normal)
Chronic kidney disease
Dementia (madness)
Dry eye (lack of adequate tears)
Dyspnoea (difficult or laboured respiration)
Fungal infection
Haematuria (presence of blood in urine)
Haemorrhage (bleeding)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Infection

60+:

Chronic kidney disease
Flushing (the warm, red condition of human skin)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasms (muscle contraction)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 23.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 21.43%
Asthma: 7 people, 16.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 11.90%
Migraine (headache): 5 people, 11.90%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 9.52%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 7.14%
Pain: 3 people, 7.14%
Immunodeficiency Common Variable: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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