Zonisamide and Lactulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Lactulose (lactulose). Common drug interactions include anxiety among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Lactulose. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

On Jul, 13, 2026

44 people who take Zonisamide and Lactulose together, and have interactions are studied.

Zonisamide and Lactulose drug interactions.

What are the common drug interactions of Zonisamide and Lactulose, by gender? *:

female:

Anxiety
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthma
Ataxia (loss of full control of bodily movements)
Attention deficit/hyperactivity disorder
Back pain
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Bipolar disorder (mood disorder)
Blood glucose increased

male:

Death
Anaemia (lack of blood)
Fall
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hospitalisation
Oedema peripheral (superficial swelling)
Abdominal discomfort
Abdominal distension
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Anion gap increased

What are the common drug interactions of Zonisamide and Lactulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Dehydration (dryness resulting from the removal of water)
Dysphagia (a condition in which swallowing is difficult or painful)
Feeding disorder (when children refuse to eat certain food groups)
Malaise (a feeling of general discomfort or uneasiness)
Respiratory disorder (respiratory disease)
Viral infection
Viral upper respiratory tract infection
Weight decreased

10-19:

Abdominal discomfort
Abdominal distension
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Anaemia (lack of blood)
Anion gap increased
Anisochromia (the uneven colouration of erythrocytes that is found in patients with sideropenia)
Arrhythmia (irregular heartbeat)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blast cell count increased

20-29:

Abdominal distension
Anxiety
Attention deficit/hyperactivity disorder
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Bipolar disorder (mood disorder)
Depression
Diarrhoea
Dyspepsia (indigestion)
Emotional distress
Enuresis (repeated inability to control urination)

30-39:

Death

40-49:

Hospitalisation
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Chronic kidney disease
Renal failure (kidney dysfunction)

50-59:

Skin striae (irregular areas of skin that look like bands, stripes, or lines)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Type 2 diabetes mellitus
Vomiting
Weight increased
White blood cell count decreased
Abdominal distension
Activities of daily living impaired

60+:

Anaemia (lack of blood)
Confusional state
Oropharyngeal candidiasis (fungal infection of oropharynx)
Psychotic disorder
Restless legs syndrome (a powerful urge to move your legs)
Thrombocytopenia (decrease of platelets in blood)
Asterixis (flapping tremor, or liver flap)
Fall
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 20.45%
Pain: 5 people, 11.36%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 6.82%
Parkinson's Disease: 3 people, 6.82%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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