Zonisamide and Leflunomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Leflunomide (leflunomide). Common drug interactions include lymphocyte count decreased among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Leflunomide. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

On Jul, 15, 2026

30 people who take Zonisamide and Leflunomide together, and have interactions are studied.

Zonisamide and Leflunomide drug interactions.

What are the common drug interactions of Zonisamide and Leflunomide, by gender? *:

female:

Lymphocyte count decreased
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Peripheral swelling
Syncope (loss of consciousness with an inability to maintain postural tone)
Animal scratch
Arthralgia (joint pain)
Back pain
Body temperature increased
Bone marrow disorder

male:

Death
Pain

What are the common drug interactions of Zonisamide and Leflunomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Bone marrow disorder
Gastrointestinal motility disorder (abnormal intestinal contractions)
Immunodeficiency common variable
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting

40-49:

Injury
Limb injury
Skin infection
Abdominal discomfort
Diarrhoea
Gastric disorder (disease of stomach)
Haematochezia (passage of stools containing blood)
Hot flush (sudden feelings of heat)
Nausea (feeling of having an urge to vomit)
Vomiting

50-59:

Lymphocyte count decreased
Animal scratch
Arthralgia (joint pain)
Back pain
Body temperature increased
Burning sensation
Contusion (a type of hematoma of tissue in which capillaries)
Discomfort
Fall
Fatigue (feeling of tiredness)

60+:

Death
Drug ineffective
Injection site bruising
Injection site pain
Peripheral swelling
Surgery

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 26.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 4 people, 13.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 13.33%
Neuropathy Peripheral (surface nerve damage): 3 people, 10.00%
High Blood Cholesterol: 3 people, 10.00%
High Blood Pressure: 3 people, 10.00%
Immunodeficiency: 3 people, 10.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 10.00%
Osteoporosis (bones weak and more likely to break): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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