Zosyn and Buscopan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zosyn (piperacillin sodium; tazobactam sodium) and Buscopan (hyoscine butylbromide). Common drug interactions include diarrhoea among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zosyn and Buscopan. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Buscopan?

Buscopan has active ingredients of hyoscine butylbromide. eHealthMe is studying from 4,828 Buscopan users. Check the latest studies of Buscopan.

On Jul, 16, 2026

16 people who take Zosyn and Buscopan together, and have interactions are studied.

What are the common drug interactions of Zosyn and Buscopan, by gender? *:

female:

Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Cardiac failure
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Hypokalaemia (low potassium)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Generalised oedema (swelling all over the body)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)

male:

Diarrhoea
Abdominal pain
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dyspnoea (difficult or laboured respiration)
Febrile neutropenia (fever with reduced white blood cells)
Gamma-glutamyltransferase increased
Gastric ulcer (stomach ulcer)
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Interstitial lung disease

What are the common drug interactions of Zosyn and Buscopan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Diarrhoea
Disease progression
Pulmonary alveolar haemorrhage (acute bleeding)

20-29:

Diarrhoea
Cardiac failure
Febrile neutropenia (fever with reduced white blood cells)
Haemoglobin decreased
Hepatic failure (liver failure)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema (fluid collection in tissue)

30-39:

n/a

40-49:

n/a

50-59:

Acute respiratory distress syndrome
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Febrile neutropenia (fever with reduced white blood cells)
Interstitial lung disease
Platelet count decreased
Pneumonia bacterial (pneumonia associated with bacterial infection)
Tongue neoplasm malignant stage unspecified

60+:

Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Oedema peripheral (superficial swelling)
Oesophageal rupture (break in oesophagus)
Pleural effusion (water on the lungs)
Rash
Relapsing fever (bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea)
Spinal compression fracture (fracture due to spinal compression on bone)
Vomiting
Hypokalaemia (low potassium)

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 43.75%
Diarrhea: 7 people, 43.75%
Febrile Neutropenia (fever with reduced white blood cells): 7 people, 43.75%
Insomnia (sleeplessness): 6 people, 37.50%
Fever: 6 people, 37.50%
Vitamin B12 Decreased: 5 people, 31.25%
Injection Site Erythema (redness at injection site): 5 people, 31.25%
Hypokalemia (low potassium): 5 people, 31.25%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 5 people, 31.25%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 31.25%

* Approximation only. Some reports may have incomplete information.

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