Zosyn and Celecoxib drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zosyn (piperacillin sodium; tazobactam sodium) and Celecoxib (celecoxib). Common drug interactions include neutrophil count decreased among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Zosyn and Celecoxib. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Celecoxib?

Celecoxib has active ingredients of celecoxib. It is often used in arthritis. eHealthMe is studying from 38,217 Celecoxib users. Check the latest studies of Celecoxib.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

36 people who take Zosyn and Celecoxib together, and have interactions are studied.

What are the common drug interactions of Zosyn and Celecoxib, by gender? *:

female:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pelvic abscess
Pyrexia (fever)
White blood cell count decreased
Abdominal pain
Anal abscess
Cholecystitis acute (rapid infection of gallbladder)
Chronic kidney disease
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Extradural abscess (pus may gather between a patient's skull and his dura)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Diarrhoea
Road traffic accident
Cellulitis (infection under the skin)
Chronic kidney disease
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Renal failure (kidney dysfunction)
Scrotal abscess (pus in scrotum)
Abscess (pus)
Anal abscess

What are the common drug interactions of Zosyn and Celecoxib, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal pain
Obstruction
Small intestinal obstruction (blockage in small intestine)

10-19:

Neutropenia (an abnormally low number of neutrophils)
White blood cell count decreased

20-29:

n/a

30-39:

n/a

40-49:

Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess limb (limb infection)
Cellulitis (infection under the skin)
Groin abscess (pus in groin)
Pelvic abscess
Vulval abscess
Extradural abscess (pus may gather between a patient's skull and his dura)
Gas gangrene (bacterial infection that produces gas within tissues)
Perineal abscess

50-59:

Urinary tract infection
Anal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess (pus)
Foot fracture
Groin abscess (pus in groin)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Leukocytosis (increased white blood cells)
Limb injury
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Diarrhoea
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pulmonary oedema (fluid accumulation in the lungs)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
White blood cell count decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)

What are the existing conditions these people have? *

Pain: 9 people, 25.00%
Type 2 Diabetes: 8 people, 22.22%
Weight Decreased: 7 people, 19.44%
Hypotension (abnormally low blood pressure): 7 people, 19.44%
High Blood Pressure: 7 people, 19.44%
Back Pain: 6 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 13.89%
Constipation: 5 people, 13.89%
Pain In Extremity: 5 people, 13.89%
Itching: 5 people, 13.89%

* Approximation only. Some reports may have incomplete information.

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