Zubsolv and Prozac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zubsolv (buprenorphine hydrochloride; naloxone hydrochloride) and Prozac (fluoxetine hydrochloride). Common drug interactions include swelling among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Zubsolv and Prozac. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Zubsolv?

Zubsolv has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 1,029 Zubsolv users. Check the latest studies of Zubsolv.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

On Jul, 26, 2026

17 people who take Zubsolv and Prozac together, and have interactions are studied.

What are the common drug interactions of Zubsolv and Prozac, by gender? *:

female:

Swelling
Swelling face
Urinary tract infection
Back injury
Fall
Onychoclasis (breaking of the nails)
Tooth loss
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chills (felling of cold)
Headache (pain in head)

male:

Drug dependence
Drug effect decreased
Headache (pain in head)
Joint swelling
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Urinary incontinence (inability to control the flow of urine and involuntary urination)

What are the common drug interactions of Zubsolv and Prozac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Inflammation
Mouth ulceration (mouth ulcers)

30-39:

Joint swelling
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Headache (pain in head)

40-49:

Chills (felling of cold)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

50-59:

Swelling
Swelling face

60+:

Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Drug Dependence: 7 people, 41.18%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 17.65%
Hereditary Angioedema (recurrent episodes of severe swelling): 3 people, 17.65%
Sleep Disorder: 2 people, 11.76%
Pain: 2 people, 11.76%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 11.76%
Stress And Anxiety: 1 person, 5.88%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.88%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.88%
Panic Disorder: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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