Zyflo cr and Zyrtec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyflo cr (zileuton) and Zyrtec (cetirizine hydrochloride). Common drug interactions include conjunctivitis allergic among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Zyflo cr and Zyrtec. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Zyflo cr?

Zyflo cr has active ingredients of zileuton. It is often used in asthma. eHealthMe is studying from 184 Zyflo cr users. Check the latest studies of Zyflo cr.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,619 Zyrtec users. Check the latest studies of Zyrtec.

On Jul, 17, 2026

31 people who take Zyflo cr and Zyrtec together, and have interactions are studied.

What are the common drug interactions of Zyflo Cr and Zyrtec, by gender? *:

female:

Conjunctivitis allergic (inflammation of the conjunctiva due to allergy)
Cough
Fatigue (feeling of tiredness)
Rhinorrhoea (watery mucus discharge from the nose)
Throat irritation
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)

male:

Pneumonia
Blood pressure increased
Burkitt's lymphoma (cancer of the lymphatic system)
Heart rate decreased
Lymphadenopathy (disease or enlargement of lymph nodes)
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the common drug interactions of Zyflo Cr and Zyrtec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

n/a

30-39:

Anaphylactic reaction (serious allergic reaction)

40-49:

Rash
Urticaria (rash of round, red welts on the skin that itch intensely)
Anaphylactic reaction (serious allergic reaction)
Chest discomfort

50-59:

Burkitt's lymphoma (cancer of the lymphatic system)
Lymphadenopathy (disease or enlargement of lymph nodes)
Nausea (feeling of having an urge to vomit)
Urinary tract infection

60+:

Blood pressure increased
Drug effect decreased
Heart rate decreased
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the existing conditions these people have? *

Asthma: 23 people, 74.19%
Allergic Rhinitis: 13 people, 41.94%
Hypersensitivity: 9 people, 29.03%
Immunodeficiency Common Variable: 3 people, 9.68%
Hiv Infection: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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