Zyrtec and Cevimeline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Cevimeline (cevimeline hydrochloride). Common drug interactions include fatigue among females and meningitis aseptic among males.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Cevimeline. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,619 Zyrtec users. Check the latest studies of Zyrtec.

What is Cevimeline?

Cevimeline has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,480 Cevimeline users. Check the latest studies of Cevimeline.

On Jul, 25, 2026

47 people who take Zyrtec and Cevimeline together, and have interactions are studied.

Zyrtec and Cevimeline drug interactions.

What are the common drug interactions of Zyrtec and Cevimeline, by gender? *:

female:

Fatigue (feeling of tiredness)
Diarrhoea
Accident at home
Foot fracture
Oropharyngeal pain
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Malaise (a feeling of general discomfort or uneasiness)
Osteochondrosis (a family of orthopaedic diseases of the joint that occur in children and adolescents)
Pruritus (severe itching of the skin)

male:

Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Sleep disorder
Stomatitis (inflammation of mucous membrane of mouth)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Drug ineffective
Dry mouth
Fatigue (feeling of tiredness)
Injection site reaction
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Muscle tightness

What are the common drug interactions of Zyrtec and Cevimeline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Feeling cold
Fluid overload (too much fluid in the blood)
Insomnia (sleeplessness)
Nephropathy (damage to or disease of a kidney)
Oxygen consumption increased
Peripheral swelling
Cardiac failure congestive

50-59:

Pruritus (severe itching of the skin)
Drug hypersensitivity
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Rales (an abnormal respiratory sound characterized by fine crackles)
Upper-airway cough syndrome
Contusion (a type of hematoma of tissue in which capillaries)
Death
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Drug ineffective
Fatigue (feeling of tiredness)

60+:

Fatigue (feeling of tiredness)
Accident at home
Hallucination (an experience involving the perception of something not present)
Immunoglobulins decreased
Malaise (a feeling of general discomfort or uneasiness)
Psychotic disorder
Renal failure (kidney dysfunction)
Weight decreased
Alopecia (absence of hair from areas of the body)
Blood albumin decreased

What are the existing conditions these people have? *

Asthma: 8 people, 17.02%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 14.89%
Immunodeficiency Common Variable: 6 people, 12.77%
Hypersensitivity: 6 people, 12.77%
Stress And Anxiety: 5 people, 10.64%
Primary Immunodeficiency Syndrome: 5 people, 10.64%
High Blood Cholesterol: 4 people, 8.51%
Salivary Hypersecretion (excess saliva secretion): 3 people, 6.38%
Pain: 3 people, 6.38%
Insomnia (sleeplessness): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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