Zyrtec and Ciprodex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Ciprodex (ciprofloxacin; dexamethasone). Common drug interactions include speech disorder among females and proteinuria among males.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Ciprodex. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,620 Zyrtec users. Check the latest studies of Zyrtec.

What is Ciprodex?

Ciprodex has active ingredients of ciprofloxacin; dexamethasone. It is often used in otitis. eHealthMe is studying from 1,887 Ciprodex users. Check the latest studies of Ciprodex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

80 people who take Zyrtec and Ciprodex together, and have interactions are studied.

What are the common drug interactions of Zyrtec and Ciprodex, by gender? *:

female:

Speech disorder
Vomiting
Wheezing (a high-pitched whistling sound made while you breath)
Rhinorrhoea (watery mucus discharge from the nose)
Abasia (inability to walk)
Arthropathy
Body height below normal
Compression fracture (fracture due to pressure caused by injury)
Depression
Drug ineffective

male:

Proteinuria (presence of protein in the urine)
Vomiting
Fungal infection
Hypoglycaemia (deficiency of glucose in the bloodstream)
Lactic acidosis (low ph in body tissues)
Myositis (inflammation of the muscles)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)
Diarrhoea

What are the common drug interactions of Zyrtec and Ciprodex, by age (0-1 to 60+)? *:

0-1:

Body height below normal
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Mitral valve incompetence (inefficient heart valve)
Oxygen saturation decreased
Premature baby
Respiratory distress (difficulty in breathing)
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other)
Tricuspid valve incompetence (inefficient heart valve)
Wheezing (a high-pitched whistling sound made while you breath)
Drug withdrawal convulsions

2-9:

Vomiting
Cough
Diarrhoea
Gastric infection (infection of stomach)
Gastrointestinal stoma complication (complication of an opening surgically made in digestive tract)
Hypersensitivity
Infusion site pruritus (severe itching at infusion site)
Infusion site urticaria (rash of round, red welts on the skin at infusion site)
Proteinuria (presence of protein in the urine)
Renal failure acute (rapid kidney dysfunction)

10-19:

Abasia (inability to walk)
Arthropathy
Compression fracture (fracture due to pressure caused by injury)
Deafness
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Oral disorder (mouth disease)
Retinal disorder (disease of retina)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Atonic seizures (minor type of seizure)

20-29:

n/a

30-39:

Depression
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Myositis (inflammation of the muscles)
Obsessive rumination (thinking and worry or rumination is an inability to gain control over recurrent, distressing thoughts, images)
Papilloma viral infection
Psychotic disorder
Salivary hypersecretion (excess saliva secretion)
Trismus (reduced opening of the jaws)
Deafness
Hypertension (high blood pressure)

40-49:

Productive cough
Pruritus (severe itching of the skin)
Pyrexia (fever)
Rhinorrhoea (watery mucus discharge from the nose)
Scar
Secretion discharge
Sinusitis (inflammation of sinus)
Sneezing
Snoring
Throat irritation

50-59:

Chronic kidney disease
Fatigue (feeling of tiredness)
Renal failure (kidney dysfunction)
Aphasia (damage to the parts of the brain that control language)
Cough
Dysphonia (speech disorder attributable to a disorder of phonation)
Laryngitis (inflammation of the larynx)
Oropharyngeal discomfort (pain or irritation of oropharynx)
Speech disorder
Diarrhoea

60+:

Acute respiratory failure
Anaemia (lack of blood)
Proteinuria (presence of protein in the urine)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Death
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Chronic kidney disease
Deafness transitory (deafness temporary)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 21 people, 26.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 13.75%
Asthma: 8 people, 10.00%
Hypersensitivity: 8 people, 10.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 8.75%
Constipation: 7 people, 8.75%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 8.75%
High Blood Pressure: 6 people, 7.50%
Cough: 5 people, 6.25%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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