Zyrtec and Levophed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Levophed (norepinephrine bitartrate). Common drug interactions include death among females and hypokalaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Levophed. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,620 Zyrtec users. Check the latest studies of Zyrtec.

What is Levophed?

Levophed has active ingredients of norepinephrine bitartrate. eHealthMe is studying from 2,047 Levophed users. Check the latest studies of Levophed.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

23 people who take Zyrtec and Levophed together, and have interactions are studied.

What are the common drug interactions of Zyrtec and Levophed, by gender? *:

female:

Death
Dizziness
Fear of disease
Fluid overload (too much fluid in the blood)
Hypotension (abnormally low blood pressure)
Multi-organ failure (multisystem organ failure)
Orthopnoea (shortness of breath (dyspnea) when lying down)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)

male:

Hypokalaemia (low potassium)
Chronic kidney disease
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Intervertebral disc degeneration (spinal disc degeneration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Osteonecrosis (death of bone)
Pain
Renal failure (kidney dysfunction)
Tooth loss

What are the common drug interactions of Zyrtec and Levophed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Malignant neoplasm progression (cancer tumour came back)
Sepsis (a severe blood infection that can lead to organ failure and death)

20-29:

Abdominal pain upper
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)
Chest discomfort

30-39:

Pain
Cholecystitis acute (rapid infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pelvic venous thrombosis (blood clot occurring inside a blood vessel and thromboses (dvts) that form in the deep veins of the legs or in the pelvic veins)
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure (kidney dysfunction)
Anxiety
Asthenia (weakness)
Dizziness
Dyspnoea (difficult or laboured respiration)

40-49:

Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)

50-59:

Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Fracture
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Intervertebral disc degeneration (spinal disc degeneration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Osteonecrosis (death of bone)
Pain
Renal tubular necrosis (death of kidney tubules)

60+:

Cardiac failure congestive
Chronic kidney disease
Hypotension (abnormally low blood pressure)
Hypokalaemia (low potassium)
Influenza
Septic shock (shock due to blood infection)
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood albumin decreased
Blood calcium decreased

What are the existing conditions these people have? *

Hypotension (abnormally low blood pressure): 8 people, 34.78%
Seasonal Allergy (allergic condition due to certain season): 6 people, 26.09%
Pain: 5 people, 21.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 17.39%
Back Pain: 4 people, 17.39%
Nausea And Vomiting: 4 people, 17.39%
Nausea (feeling of having an urge to vomit): 4 people, 17.39%
Depression: 4 people, 17.39%
Gout (uric acid crystals building up in the body): 3 people, 13.04%
Cardiac Failure: 3 people, 13.04%

* Approximation only. Some reports may have incomplete information.

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