Zyrtec and Lotronex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Lotronex (alosetron hydrochloride). Common drug interactions include blood in stool among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Lotronex. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,619 Zyrtec users. Check the latest studies of Zyrtec.

What is Lotronex?

Lotronex has active ingredients of alosetron hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 6,841 Lotronex users. Check the latest studies of Lotronex.

On Jul, 28, 2026

41 people who take Zyrtec and Lotronex together, and have interactions are studied.

What are the common drug interactions of Zyrtec and Lotronex, by gender? *:

female:

Blood in stool
Drug ineffective
Gallbladder disorder
Large intestinal ulcer
Sinusitis (inflammation of sinus)
Abdominal distension
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Colitis (inflammation of colon)
Diarrhoea haemorrhagic (bloody diarrhoea)

male:

Abdominal pain
Blood in stool
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Tunnel vision (the loss of peripheral vision with retention of central vision)

What are the common drug interactions of Zyrtec and Lotronex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Gallbladder disorder
Procedural nausea
Procedural vomiting
Blood in stool
Constipation
Quality of life decreased
Abdominal distension
Diarrhoea
Dry mouth

30-39:

n/a

40-49:

Blood in stool
Constipation
Diarrhoea
Drug administration error
Muscle cramp (painful sensation caused by muscle contraction)
Nausea (feeling of having an urge to vomit)
Sedation
Sinusitis (inflammation of sinus)
Taste disturbance
Taste loss

50-59:

Abdominal pain
Constipation
Colitis (inflammation of colon)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Intestinal obstruction
Megacolon (a very dilated colon)
Toxic dilatation of colon (enlargement of colon due to toxin)
Vomiting

60+:

n/a

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 9.76%
Premenstrual Syndrome: 3 people, 7.32%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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