Zyrtec and Premphase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Premphase (estrogens, conjugated; medroxyprogesterone acetate). Common drug interactions include anxiety among females.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Premphase. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,620 Zyrtec users. Check the latest studies of Zyrtec.

What is Premphase?

Premphase has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 2,262 Premphase users. Check the latest studies of Premphase.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

30 people who take Zyrtec and Premphase together, and have interactions are studied.

What are the common drug interactions of Zyrtec and Premphase, by gender? *:

female:

Anxiety
Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Pyrexia (fever)
Vomiting
Anaemia of chronic disease
Anaphylactic reaction (serious allergic reaction)
Angioedema (rapid swelling of the dermis)
Atelectasis (partial or complete collapse of the lung)
Bone disorder

male:

n/a

What are the common drug interactions of Zyrtec and Premphase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Major depressive disorder (a condition characterized by a long-lasting depressed mood or marked loss of interest or pleasure)
Abdominal pain
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia of chronic disease
Anaphylactic reaction (serious allergic reaction)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angioedema (rapid swelling of the dermis)
Anxiety
Arrhythmia (irregular heartbeat)
Arteritis (inflammation of the walls of arteries)

30-39:

n/a

40-49:

Anxiety
Depression
Nausea (feeling of having an urge to vomit)
Cellulitis (infection under the skin)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Fungal infection
Nephrolithiasis (calculi in the kidneys)

50-59:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry skin
Dysarthria (speech disorder)
Dystonia (abnormal muscle tone)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Endocarditis (inflammation in heart muscle)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Fall
Fluid overload (too much fluid in the blood)
Hyperglycaemia (high blood sugar)

60+:

Abdominal pain
Anaemia of chronic disease
Cardiac failure chronic
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dental caries
Dental discomfort
Diarrhoea
Diverticulum intestinal haemorrhagic (a pouch that is attached to the first part of the small intestine with bleeding)

What are the existing conditions these people have? *

Stress And Anxiety: 14 people, 46.67%
Pain In Jaw: 12 people, 40.00%
Multiple Myeloma (cancer of the plasma cells): 12 people, 40.00%
Pain: 6 people, 20.00%
High Blood Pressure: 3 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.00%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 3 people, 10.00%
Quit Smoking: 2 people, 6.67%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 2 people, 6.67%
Depression: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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