Zyrtec and Silvadene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Silvadene (silver sulfadiazine). Common drug interactions include irritability among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Silvadene. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,619 Zyrtec users. Check the latest studies of Zyrtec.

What is Silvadene?

Silvadene has active ingredients of silver sulfadiazine. eHealthMe is studying from 1,161 Silvadene users. Check the latest studies of Silvadene.

On Jul, 18, 2026

52 people who take Zyrtec and Silvadene together, and have interactions are studied.

What are the common drug interactions of Zyrtec and Silvadene, by gender? *:

female:

Irritability
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Mobility decreased (ability to move is reduced)
Monoparesis (one limb is very weak, but not completely paralyzed)
Muscle tightness
Muscular weakness (muscle weakness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Night sweats (sweating in night)
Osteopenia (a condition where bone mineral density is lower than normal)
Overdose

male:

Cough
Decreased appetite
Diarrhoea
Erythema (redness of the skin)
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Heart rate decreased
Hospitalisation
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia (reduced sense of touch or sensation)

What are the common drug interactions of Zyrtec and Silvadene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cough
Dyspnoea (difficult or laboured respiration)
Respiratory syncytial virus infection (viral disease of respiratory system)
Tracheobronchitis (an inflammation or infection, which affects the trachea and bronchi of respiratory tract)
Pulmonary arterial pressure increased
Pyrexia (fever)
Secretion discharge
Viral infection

10-19:

n/a

20-29:

Altered state of consciousness (altered state of mind)
Anxiety
Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Botulism (food poisoning caused by botulinum growing)
Breath sounds
Cellulitis (infection under the skin)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dysphagia (a condition in which swallowing is difficult or painful)
Eye movement disorder

30-39:

Cardiac disorder
Cerebral disorder (brain disease)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Road traffic accident
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Weight decreased
Infected cyst
Staphylococcal infection (an infection with staphylococcus bacteria)

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Application site discolouration
Drug ineffective
Rash
Scar
Wound infection
Fatigue (feeling of tiredness)
Abdominal pain
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)

60+:

Fall
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Drug ineffective
Dysarthria (speech disorder)
Diarrhoea
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Gingival disorder (gum disease)
Joint swelling
Neuropathy peripheral (surface nerve damage)
Peripheral swelling

What are the existing conditions these people have? *

Pain: 17 people, 32.69%
Muscle Spasms (muscle contraction): 13 people, 25.00%
Neuropathy Peripheral (surface nerve damage): 12 people, 23.08%
Hypersensitivity: 11 people, 21.15%
Depression: 10 people, 19.23%
High Blood Cholesterol: 9 people, 17.31%
Diabetes: 9 people, 17.31%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 15.38%
Urinary Tract Infection: 8 people, 15.38%
High Blood Pressure: 7 people, 13.46%

* Approximation only. Some reports may have incomplete information.

Do you take Zyrtec and Silvadene?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously