Zyrtec and Tepezza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Tepezza (teprotumumab-trbw). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Tepezza. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,619 Zyrtec users. Check the latest studies of Zyrtec.

What is Tepezza?

Tepezza has active ingredients of teprotumumab-trbw. eHealthMe is studying from 3,632 Tepezza users. Check the latest studies of Tepezza.

On Jul, 06, 2026

18 people who take Zyrtec and Tepezza together, and have interactions are studied.

What are the common drug interactions of Zyrtec and Tepezza, by gender? *:

female:

Fatigue (feeling of tiredness)
Muscle spasms (muscle contraction)
Tinnitus (a ringing in the ears)
Skin wrinkling (wrinkle on skin)
Pruritus (severe itching of the skin)
Ear discomfort
Rash papular (redness with papule)
Dry skin
Headache (pain in head)
Alopecia (absence of hair from areas of the body)

male:

n/a

What are the common drug interactions of Zyrtec and Tepezza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dry skin
Fatigue (feeling of tiredness)
Pruritus (severe itching of the skin)

50-59:

Dry skin
Ear discomfort
Headache (pain in head)
Pruritus (severe itching of the skin)
Rash papular (redness with papule)

60+:

Fatigue (feeling of tiredness)
Muscle spasms (muscle contraction)
Tinnitus (a ringing in the ears)
Skin wrinkling (wrinkle on skin)
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Dry skin
Eye pain
Flushing (the warm, red condition of human skin)
Headache (pain in head)

What are the existing conditions these people have? *

Endocrine Ophthalmopathy (increased water content of retroocular orbital tissues; associated with thyroid disease, usually hyperthyroidism): 13 people, 72.22%
Type 2 Diabetes: 2 people, 11.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.11%
Neuropathy Peripheral (surface nerve damage): 2 people, 11.11%
Hypersensitivity: 2 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 2 people, 11.11%
Stress And Anxiety: 1 person, 5.56%
Pain: 1 person, 5.56%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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