Zyrtec and Treximet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Treximet (naproxen sodium; sumatriptan succinate). Common drug interactions include nausea among females and atrioventricular block among males.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Treximet. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,620 Zyrtec users. Check the latest studies of Zyrtec.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

48 people who take Zyrtec and Treximet together, and have interactions are studied.

What are the common drug interactions of Zyrtec and Treximet, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Dysuria (painful or difficult urination)
Anxiety
Insomnia (sleeplessness)
Sinusitis (inflammation of sinus)
Vomiting
Foot fracture
Hysterectomy
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)

male:

Atrioventricular block (heart block)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Hypertension (high blood pressure)
Obesity (having too much body fat)
Therapeutic response unexpected
Angina pectoris (chest pain due to ischemia of the heart muscle)
Rib fracture
Road traffic accident
Weight decreased

What are the common drug interactions of Zyrtec and Treximet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Flushing (the warm, red condition of human skin)

20-29:

Rash
Retching (strong involuntary effort to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting
Heart rate decreased
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Anastomotic stenosis
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

30-39:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Atrioventricular block (heart block)
Depression
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Night sweats (sweating in night)

40-49:

Atrioventricular block (heart block)
Headache (pain in head)
Influenza
Nausea (feeling of having an urge to vomit)
Pain
Abdominal pain upper
Anxiety
Chronic kidney disease
Hepatic enzyme increased
Hepatitis (inflammation of the liver)

50-59:

Benign prostatic hyperplasia (benign enlargement of the prostate)
Hypertension (high blood pressure)
Obesity (having too much body fat)
Therapeutic response unexpected
Diarrhoea
Hot flush (sudden feelings of heat)
Insomnia (sleeplessness)
Weight decreased

60+:

Oropharyngeal pain
Vomiting
Nasopharyngitis (inflammation of the nasopharynx)
Obstruction
Respiratory tract infection
Rhinorrhoea (watery mucus discharge from the nose)
Sinus congestion (blockage of sinus)
Sinusitis (inflammation of sinus)
Abdominal pain
Anxiety

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 29.17%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 14.58%
Pain: 6 people, 12.50%
Depression: 5 people, 10.42%
Seasonal Allergy (allergic condition due to certain season): 4 people, 8.33%
Hypersensitivity: 4 people, 8.33%
Headache (pain in head): 4 people, 8.33%
Stress And Anxiety: 3 people, 6.25%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 3 people, 6.25%
Constipation: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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