Rapaflo and Zytiga drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rapaflo (silodosin) and Zytiga (abiraterone acetate). Common drug interactions include fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Rapaflo and Zytiga. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Rapaflo?

Rapaflo has active ingredients of silodosin. It is often used in prostate examination abnormal. eHealthMe is studying from 3,929 Rapaflo users. Check the latest studies of Rapaflo.

What is Zytiga?

Zytiga has active ingredients of abiraterone acetate. It is often used in prostate cancer metastatic. eHealthMe is studying from 29,928 Zytiga users. Check the latest studies of Zytiga.



On May, 23, 2026

45 people who take Rapaflo and Zytiga together, and have interactions are studied.

Rapaflo and Zytiga drug interactions.

What are the common drug interactions of Rapaflo and Zytiga, by gender? *:

female:

n/a

male:

  1. Fatigue (feeling of tiredness)
  2. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  3. Abasia (inability to walk)
  4. Blood creatinine increased
  5. Death
  6. Disease progression
  7. Hepatotoxicity (chemical-driven liver damage)
  8. Malignant neoplasm progression (cancer tumour came back)
  9. Prostatic specific antigen increased
  10. Constipation

What are the common drug interactions of Rapaflo and Zytiga, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  2. Fall
  3. Disease progression
  4. Drug ineffective
  5. Hepatotoxicity (chemical-driven liver damage)
  6. Malignant neoplasm progression (cancer tumour came back)
  7. Prostatic specific antigen increased
  8. Asthenia (weakness)
  9. Dizziness
  10. Gait disturbance

What are the existing conditions these people have? *

  1. Prostate Cancer: 30 people, 66.67%
  2. High Blood Pressure: 7 people, 15.56%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 13.33%
  4. High Blood Cholesterol: 5 people, 11.11%
  5. Diabetes: 5 people, 11.11%
  6. Urinary Retention (the inability to completely or partially empty the bladder): 4 people, 8.89%
  7. Stress And Anxiety: 4 people, 8.89%
  8. Pain In Extremity: 4 people, 8.89%
  9. Anaemia (lack of blood): 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

Do you take Rapaflo and Zytiga?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rapaflo and Zytiga:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rapaflo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zytiga:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rapaflo and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zytiga and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on silodosin and abiraterone acetate (the active ingredients of Rapaflo and Zytiga, respectively), and Rapaflo and Zytiga (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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