Pliaglis side effects, by duration, gender and age (a phase IV clinical study of FDA data)

female:

1. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
2. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
3. Bradycardia (abnormally slow heart action)
4. Deformity (disfigurement)
5. Drug ineffective
6. Activities of daily living impaired
7. Application site discolouration
8. Atrioventricular block (heart block)
9. Chemical burns of eye
10. Conjunctivitis (pink eye)

male:

1. Burning sensation
2. Dizziness
3. Drug ineffective
4. Epidermal necrosis (skin condition that is usually caused by a reaction to drugs)
5. Erythema (redness of the skin)
6. Joint swelling
7. Wound

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

1. Erythema (redness of the skin)
2. Epidermal necrosis (skin condition that is usually caused by a reaction to drugs)
3. Skin swelling

30-39:

1. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
2. Dizziness
3. Drug ineffective

40-49:

1. Erythema (redness of the skin)
2. Application site discolouration
3. Drug ineffective
4. Joint swelling

50-59:

1. Anxiety
2. Burning sensation
3. Activities of daily living impaired
4. Angioedema (rapid swelling of the dermis)
5. Dizziness
6. Erythema (redness of the skin)
7. Eyelid oedema (eyelids are swollen and contain excessive fluid)

60+:

1. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
2. Deformity (disfigurement)
3. Depression
4. Drug ineffective
5. Injection site bruising

< 1 month:

1. Erythema (redness of the skin)
2. Anxiety
3. Conjunctivitis (pink eye)
4. Epidermal necrosis (skin condition that is usually caused by a reaction to drugs)
5. Eyelid oedema (eyelids are swollen and contain excessive fluid)
6. Joint swelling
7. Skin swelling
8. Drug ineffective
9. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
10. Bradycardia (abnormally slow heart action)

1 - 6 months:

n/a

6 - 12 months:

n/a

1 - 2 years:

n/a

2 - 5 years:

n/a

5 - 10 years:

n/a

10+ years:

n/a

not specified:

1. Erythema (redness of the skin)
2. Drug ineffective
3. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
4. Angioedema (rapid swelling of the dermis)
5. Activities of daily living impaired
6. Application site discolouration
7. Atrioventricular block (heart block)
8. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
9. Conjunctivitis (pink eye)
10. Depression