Vitamin d3 and Interstitial nephritis - a phase IV clinical study of FDA data

Summary:

Interstitial nephritis is reported as a side effect among people who take Vitamin d3 (cholecalciferol), especially for people who are male, 60+ old, also take Amlodipine, and have High blood pressure.

The phase IV clinical study analyzes which people have Interstitial nephritis when taking Vitamin d3. It is created by eHealthMe based on reports of 31,612 people who have side effects when taking Vitamin d3 from the FDA, and is updated regularly.

What is Vitamin d3?

Vitamin d3 has active ingredients of cholecalciferol. It is often used in heart health. eHealthMe is studying from 32,172 Vitamin d3 users. Check the latest studies of Vitamin d3.

What is Interstitial nephritis?

Interstitial nephritis (inflammation of the kidney) is found to be associated with 1,085 drugs and 1,568 conditions by eHealthMe. Check the latest studies of Interstitial nephritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

31,612 people reported to have side effects when taking Vitamin d3.
Among them, 18 people (0.06%) have Interstitial nephritis.

Could Vitamin d3 cause Interstitial nephritis?

Among these 18 people:

What is the gender of people who have Interstitial nephritis when taking Vitamin d3? *

female: 29.41 %
male: 70.59 %

What is the age of people who have Interstitial nephritis when taking Vitamin d3? *

What are other drugs people take besides Vitamin d3? *

What are other side effects people have besides Interstitial nephritis? *

Acute Kidney Failure: 8 people, 44.44%
Chronic Kidney Disease: 6 people, 33.33%
Diarrhea: 5 people, 27.78%
Oedema Peripheral (superficial swelling): 3 people, 16.67%
High Blood Pressure: 2 people, 11.11%
Nausea And Vomiting: 2 people, 11.11%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 11.11%
Blood Creatinine Increased: 2 people, 11.11%
Dehydration (dryness resulting from the removal of water): 2 people, 11.11%
Face Oedema (swelling of face): 2 people, 11.11%

What are the existing conditions these people have? *

High Blood Pressure: 9 people, 50.00%
Pain: 7 people, 38.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 33.33%
High Blood Cholesterol: 5 people, 27.78%
Stress And Anxiety: 4 people, 22.22%
Infection: 3 people, 16.67%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 16.67%
Inflammation: 3 people, 16.67%
Type 2 Diabetes: 3 people, 16.67%
Gastric Ph Decreased: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin d3 and have Interstitial nephritis?

- Check whether Interstitial nephritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin d3:

Vitamin d3 (32,172 reports)

Browse all side effects of Vitamin d3:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Interstitial nephritis:

Interstitial nephritis (1,085 drugs)

Browse all the conditions that are associated with Interstitial nephritis:

Interstitial nephritis (1,568 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cholecalciferol (the active ingredients of Vitamin d3) and Vitamin d3 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.