Provocholine side effects, by duration, gender and age (a phase IV clinical study of FDA data)

female:

1. Anaemia (lack of blood)
2. Anxiety
3. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
4. Cardiac failure
5. Chest pain
6. Cough
7. Dyspnoea (difficult or laboured respiration)
8. Pruritus (severe itching of the skin)
9. Abdominal pain upper
10. Acne (skin problems that cause pimples)

male:

1. Drug ineffective
2. Abdominal distension
3. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
4. Testicular swelling (swelling of testes)
5. Angiofibroma (small, reddish brown or even flesh-coloured, smooth, shiny, 0.1- to 0.3 cm papules present over the sides of the nose and the medial portions of the cheeks)
6. Anxiety
7. Arthralgia (joint pain)
8. Asthenia (weakness)
9. Diarrhoea
10. Eye irritation

0-1:

n/a

2-9:

n/a

10-19:

1. Drug effect decreased

20-29:

n/a

30-39:

1. Drug ineffective
2. Abdominal pain upper
3. Arthralgia (joint pain)
4. Consciousness fluctuating
5. Forced expiratory volume decreased (decreased lung expired air volume)
6. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
7. Pruritus (severe itching of the skin)

40-49:

1. Arthritis (form of joint disorder that involves inflammation of one or more joints)
2. Blood pressure decreased
3. Chest pain
4. Cough

50-59:

1. Anaemia (lack of blood)
2. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
3. Acne (skin problems that cause pimples)
4. Anger
5. Angiofibroma (small, reddish brown or even flesh-coloured, smooth, shiny, 0.1- to 0.3 cm papules present over the sides of the nose and the medial portions of the cheeks)
6. Anxiety
7. Cough
8. Headache (pain in head)

60+:

1. Dyspnoea (difficult or laboured respiration)
2. Anxiety
3. Asthenia (weakness)
4. Cardiac failure
5. Chest pain
6. Eye irritation
7. Flushing (the warm, red condition of human skin)
8. Frequent bowel movements
9. Testicular swelling (swelling of testes)

< 1 month:

1. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
2. Abdominal pain upper
3. Cardiac failure
4. Chest pain
5. Pruritus (severe itching of the skin)

1 - 6 months:

n/a

6 - 12 months:

n/a

1 - 2 years:

n/a

2 - 5 years:

n/a

5 - 10 years:

n/a

10+ years:

n/a

not specified:

1. Headache (pain in head)
2. Abdominal distension
3. Acne (skin problems that cause pimples)
4. Anger
5. Angiofibroma (small, reddish brown or even flesh-coloured, smooth, shiny, 0.1- to 0.3 cm papules present over the sides of the nose and the medial portions of the cheeks)
6. Arthralgia (joint pain)
7. Arthritis (form of joint disorder that involves inflammation of one or more joints)
8. Asthenia (weakness)
9. Blood pressure decreased
10. Cardiac failure