Abilify and Sleeping difficulty - a phase IV clinical study of FDA data

Summary:

Sleeping difficulty is reported as a side effect among people who take Abilify (aripiprazole), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Seroquel, and have Schizophrenia.

The phase IV clinical study analyzes which people have Sleeping difficulty when taking Abilify. It is created by eHealthMe based on reports of 97,308 people who have side effects when taking Abilify from the FDA, and is updated regularly.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,443 Abilify users. Check the latest studies of Abilify.

What is Sleeping difficulty?

Sleeping difficulty (difficult sleeping) is found to be associated with 4,199 drugs and 5,350 conditions by eHealthMe. Check the latest studies of Sleeping difficulty.



On Dec, 18, 2025

97,308 people reported to have side effects when taking Abilify.
Among them, 3,448 people (3.54%) have Sleeping difficulty.

Could Abilify cause Sleeping difficulty?

Among these 3,448 people:

How long have people been on Abilify when they have Sleeping difficulty? *

  • < 1 month: 46.61 %
  • 1 - 6 months: 25.91 %
  • 6 - 12 months: 7.48 %
  • 1 - 2 years: 6.61 %
  • 2 - 5 years: 6.78 %
  • 5 - 10 years: 4.7 %
  • 10+ years: 1.91 %

What is the gender of people who have Sleeping difficulty when taking Abilify? *

  • female: 59.79 %
  • male: 40.21 %

What is the age of people who have Sleeping difficulty when taking Abilify? *

  • 0-1: 0.26 %
  • 2-9: 1.43 %
  • 10-19: 5.38 %
  • 20-29: 18.8 %
  • 30-39: 17.67 %
  • 40-49: 22.71 %
  • 50-59: 18.41 %
  • 60+: 15.33 %

What are other drugs people take besides Abilify? *

  1. Seroquel: 360 people, 10.44%
  2. Zyprexa: 331 people, 9.60%
  3. Lamictal: 248 people, 7.19%
  4. Risperdal: 220 people, 6.38%
  5. Klonopin: 219 people, 6.35%
  6. Cymbalta: 209 people, 6.06%
  7. Xanax: 198 people, 5.74%
  8. Zoloft: 195 people, 5.66%
  9. Lexapro: 178 people, 5.16%
  10. Depakote: 174 people, 5.05%

What are other side effects people have besides Sleeping difficulty? *

  1. Stress And Anxiety: 855 people, 24.80%
  2. Agitation (state of anxiety or nervous excitement): 619 people, 17.95%
  3. Fatigue (feeling of tiredness): 487 people, 14.12%
  4. Suicidal Ideation: 487 people, 14.12%
  5. Weight Increased: 419 people, 12.15%
  6. Nausea (feeling of having an urge to vomit): 399 people, 11.57%
  7. Headache (pain in head): 377 people, 10.93%
  8. Dizziness: 329 people, 9.54%
  9. Drowsiness: 293 people, 8.50%
  10. Drug Ineffective: 278 people, 8.06%

What are the existing conditions these people have? *

  1. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 524 people, 15.20%
  2. Stress And Anxiety: 332 people, 9.63%
  3. Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 189 people, 5.48%
  4. Psychotic Disorder: 137 people, 3.97%
  5. Schizoaffective Disorder (a mental disorder characterized by disordered thought): 135 people, 3.92%
  6. Sleep Disorder: 130 people, 3.77%
  7. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 113 people, 3.28%
  8. Pain: 97 people, 2.81%
  9. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 91 people, 2.64%
  10. High Blood Pressure: 72 people, 2.09%

* Approximation only. Some reports may have incomplete information.

Do you take Abilify and have Sleeping difficulty?

- Check whether Sleeping difficulty is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Abilify:

Sleeping difficulty treatments and more:

How severe was Sleeping difficulty and when was it recovered:

Expand to all the drugs that have ingredients of aripiprazole:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Abilify side effects:

Browse all side effects of Abilify:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Sleeping difficulty:

Browse all the drugs that are associated with Sleeping difficulty:

Common conditions associated with Sleeping difficulty:

Browse all the conditions that are associated with Sleeping difficulty:

Drugs similar to Abilify and Sleeping difficulty :

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on aripiprazole (the active ingredients of Abilify) and Abilify (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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