1. Home
  2. Analysis
  3. Abreva
  4. Nonspecific-reaction

Abreva and Nonspecific reaction - a phase IV clinical study of FDA data

Summary:

Nonspecific reaction is reported as a side effect among people who take Abreva (docosanol), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Miralax, and have Oral herpes.

The phase IV clinical study analyzes which people have Nonspecific reaction when taking Abreva. It is created by eHealthMe based on reports of 17,058 people who have side effects when taking Abreva from the FDA, and is updated regularly.

What is Abreva?

Abreva has active ingredients of docosanol. It is often used in herpes labialis (oral herpes simplex). eHealthMe is studying from 17,071 Abreva users. Check the latest studies of Abreva.

What is Nonspecific reaction?

Nonspecific reaction (unspecified reaction) is found to be associated with 469 drugs and 436 conditions by eHealthMe. Check the latest studies of Nonspecific reaction.

On Jul, 09, 2026

17,058 people reported to have side effects when taking Abreva.
Among them, 30 people (0.18%) have Nonspecific reaction.

Could Abreva cause Nonspecific reaction?

Among these 30 people:

How long have people been on Abreva when they have Nonspecific reaction? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Nonspecific reaction when taking Abreva? *

  • female: 78.57 %
  • male: 21.43 %

What is the age of people who have Nonspecific reaction when taking Abreva? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 9.09 %
  • 20-29: 4.55 %
  • 30-39: 27.27 %
  • 40-49: 18.18 %
  • 50-59: 18.18 %
  • 60+: 22.73 %

What are other drugs people take besides Abreva? *

  1. Vitamin D: 1 person, 3.33%
  2. Tylenol: 1 person, 3.33%
  3. Tamiflu: 1 person, 3.33%
  4. Sinemet: 1 person, 3.33%
  5. Seroquel: 1 person, 3.33%
  6. Remeron: 1 person, 3.33%
  7. Protonix: 1 person, 3.33%
  8. Oxycodone: 1 person, 3.33%
  9. Nuplazid: 1 person, 3.33%
  10. Miralax: 1 person, 3.33%

What are other side effects people have besides Nonspecific reaction? *

  1. Oral Herpes (viral infection of mouth): 9 people, 30.00%
  2. Application Site Pain: 4 people, 13.33%
  3. Drug Ineffective: 4 people, 13.33%
  4. Pain: 3 people, 10.00%
  5. Drug Administration Error: 3 people, 10.00%
  6. Swelling Face: 3 people, 10.00%
  7. Herpes Simplex (herpes simplex is a common viral infection): 2 people, 6.67%
  8. Lip Swelling: 2 people, 6.67%
  9. Burning Sensation: 2 people, 6.67%
  10. Acne (skin problems that cause pimples): 2 people, 6.67%

What are the existing conditions these people have? *

  1. Oral Herpes (viral infection of mouth): 17 people, 56.67%
  2. Hallucinations (sensations that appear real but are created by your mind): 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Abreva and have Nonspecific reaction?

- Check whether Nonspecific reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Abreva:

Nonspecific reaction treatments and more:

How severe was Nonspecific reaction and when was it recovered:

Expand to all the drugs that have ingredients of docosanol:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Abreva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nonspecific reaction:

Browse all the conditions that are associated with Nonspecific reaction:

How the study uses the data?

The study uses data from the FDA. It is based on docosanol (the active ingredients of Abreva) and Abreva (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.