Accutane and Palindromic rheumatism - a phase IV clinical study of FDA data

Summary:

Palindromic rheumatism is reported as a side effect among people who take Accutane (isotretinoin), especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months also take Depo-Provera, and have Birth control.

The phase IV clinical study analyzes which people have Palindromic rheumatism when taking Accutane. It is created by eHealthMe based on reports of 33,410 people who have side effects when taking Accutane from the FDA, and is updated regularly.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

What is Palindromic rheumatism?

Palindromic rheumatism (sudden and rapidly developing attacks of arthritis) is found to be associated with 22 drugs and 63 conditions by eHealthMe. Check the latest studies of Palindromic rheumatism.

On Jul, 21, 2026

33,410 people reported to have side effects when taking Accutane.
Among them, 16 people (0.05%) have Palindromic rheumatism.

Could Accutane cause Palindromic rheumatism?

Among these 16 people:

How long have people been on Accutane when they have Palindromic rheumatism? *

What is the gender of people who have Palindromic rheumatism when taking Accutane? *

female: 100 %
male: 0.0 %

What is the age of people who have Palindromic rheumatism when taking Accutane? *

What are other drugs people take besides Accutane? *

What are other side effects people have besides Palindromic rheumatism? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 16 people, 100.00%
Autoimmune Disorder (a condition in which the immune system attacks the body's normal substances and tissue): 16 people, 100.00%
Bone Disorder: 16 people, 100.00%
Rectal Haemorrhage (bleeding from anus): 16 people, 100.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 16 people, 100.00%
Colitis (inflammation of colon): 16 people, 100.00%
Musculoskeletal Disorder (disease of the body's muscles, joints, tendons, ligaments and nerves): 16 people, 100.00%
Osteopenia (a condition where bone mineral density is lower than normal): 16 people, 100.00%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 16 people, 100.00%
Intestinal Haemorrhage (bleeding from intestine): 16 people, 100.00%

What are the existing conditions these people have? *

Birth Control: 2 people, 12.50%
Stress And Anxiety: 1 person, 6.25%
Osteoporosis (bones weak and more likely to break): 1 person, 6.25%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 6.25%
Migraine (headache): 1 person, 6.25%
Asthma: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Accutane and have Palindromic rheumatism?

- Check whether Palindromic rheumatism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Accutane:

Accutane (35,221 reports)

Browse all side effects of Accutane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Palindromic rheumatism:

Palindromic rheumatism (22 drugs)

Browse all the conditions that are associated with Palindromic rheumatism:

Palindromic rheumatism (63 conditions)

Related publications that referenced our studies

Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin (the active ingredients of Accutane) and Accutane (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.