Acetylcysteine and Fluid overload - a phase IV clinical study of FDA data

Summary:

Fluid overload is reported as a side effect among people who take Acetylcysteine (acetylcysteine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aldactone, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Fluid overload when taking Acetylcysteine. It is created by eHealthMe based on reports of 11,475 people who have side effects when taking Acetylcysteine from the FDA, and is updated regularly.

What is Acetylcysteine?

Acetylcysteine has active ingredients of acetylcysteine. It is often used in cough. eHealthMe is studying from 11,563 Acetylcysteine users. Check the latest studies of Acetylcysteine.

What is Fluid overload?

Fluid overload (too much fluid in the blood) is found to be associated with 1,023 drugs and 1,051 conditions by eHealthMe. Check the latest studies of Fluid overload.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

11,475 people reported to have side effects when taking Acetylcysteine.
Among them, 28 people (0.24%) have Fluid overload.

Could Acetylcysteine cause Fluid overload?

Among these 28 people:

How long have people been on Acetylcysteine when they have Fluid overload? *

What is the gender of people who have Fluid overload when taking Acetylcysteine? *

female: 63.16 %
male: 36.84 %

What is the age of people who have Fluid overload when taking Acetylcysteine? *

What are other drugs people take besides Acetylcysteine? *

What are other side effects people have besides Fluid overload? *

Nausea (feeling of having an urge to vomit): 12 people, 42.86%
Diarrhea: 10 people, 35.71%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 10 people, 35.71%
Nausea And Vomiting: 9 people, 32.14%
Sinusitis (inflammation of sinus): 8 people, 28.57%
Acute Kidney Failure: 8 people, 28.57%
Fainting (loss of consciousness and postural tone): 8 people, 28.57%
Hypotension (abnormally low blood pressure): 8 people, 28.57%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 7 people, 25.00%
Rashes (redness): 7 people, 25.00%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 28.57%
Meningitis Fungal (fungal inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 6 people, 21.43%
Primary Myelofibrosis (primary disorder of the bone marrow): 3 people, 10.71%
High Blood Pressure: 3 people, 10.71%
Gout (uric acid crystals building up in the body): 3 people, 10.71%
Cardiac Failure: 3 people, 10.71%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 10.71%
Systemic Candida (whole body fungal infection): 2 people, 7.14%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 7.14%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Acetylcysteine and have Fluid overload?

- Check whether Fluid overload is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acetylcysteine:

Acetylcysteine (11,563 reports)

Fluid overload treatments and more:

Fluid overload (20,385 reports)

Browse all side effects of Acetylcysteine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid overload:

Fluid overload (1,023 drugs)

Browse all the conditions that are associated with Fluid overload:

Fluid overload (1,051 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetylcysteine (the active ingredients of Acetylcysteine) and Acetylcysteine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.