Aciphex and Dementia - a phase IV clinical study of FDA data

Summary:

Dementia is reported as a side effect among people who take Aciphex (rabeprazole sodium), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Prilosec, and have Depression.

The phase IV clinical study analyzes which people have Dementia when taking Aciphex. It is created by eHealthMe based on reports of 24,594 people who have side effects when taking Aciphex from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Dementia?

Dementia (madness) is found to be associated with 1,210 drugs and 1,806 conditions by eHealthMe. Check the latest studies of Dementia.

On Apr, 22, 2026

24,594 people reported to have side effects when taking Aciphex.
Among them, 32 people (0.13%) have Dementia.

Among these 32 people:

How long have people been on Aciphex when they have Dementia? *

What is the gender of people who have Dementia when taking Aciphex? *

female: 62.07 %
male: 37.93 %

What is the age of people who have Dementia when taking Aciphex? *

What are other drugs people take besides Aciphex? *

What are other side effects people have besides Dementia? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 9 people, 28.12%
High Blood Pressure: 9 people, 28.12%
Fatigue (feeling of tiredness): 7 people, 21.88%
Confusional State: 7 people, 21.88%
Anaemia (lack of blood): 7 people, 21.88%
Chronic Kidney Disease: 6 people, 18.75%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 18.75%
Nausea (feeling of having an urge to vomit): 6 people, 18.75%
Dyspnea (difficult or laboured breathing): 5 people, 15.62%
Depression: 5 people, 15.62%

What are the existing conditions these people have? *

Depression: 6 people, 18.75%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 15.62%
Multiple Allergies (allergy to multiple agents): 3 people, 9.38%
Stress And Anxiety: 3 people, 9.38%
Osteoporosis (bones weak and more likely to break): 3 people, 9.38%
Vitamin B12 Deficiency: 2 people, 6.25%
High Blood Pressure: 2 people, 6.25%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 2 people, 6.25%
Hypoparathyroidism (inadequate secretion of parathyroid hormone resulting in abnormally low levels of calcium in the blood): 2 people, 6.25%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and have Dementia?

- Check whether Dementia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aciphex:

Aciphex (25,301 reports)

Dementia treatments and more:

Dementia (44,271 reports)

Browse all side effects of Aciphex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dementia:

Dementia (1,210 drugs)

Browse all the conditions that are associated with Dementia:

Dementia (1,806 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium (the active ingredients of Aciphex) and Aciphex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.