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Aciphex and Osteolysis - a phase IV clinical study of FDA data

Summary:

Osteolysis is reported as a side effect among people who take Aciphex (rabeprazole sodium), especially for people who are female, 50-59 old, also take Aredia, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Osteolysis when taking Aciphex. It is created by eHealthMe based on reports of 24,594 people who have side effects when taking Aciphex from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Osteolysis?

Osteolysis (dissolution of bone) is found to be associated with 688 drugs and 407 conditions by eHealthMe. Check the latest studies of Osteolysis.

On Jul, 06, 2026

24,594 people reported to have side effects when taking Aciphex.
Among them, 28 people (0.11%) have Osteolysis.

Could Aciphex cause Osteolysis?

Among these 28 people:

What is the gender of people who have Osteolysis when taking Aciphex? *

  • female: 60.71 %
  • male: 39.29 %

What is the age of people who have Osteolysis when taking Aciphex? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 4.17 %
  • 30-39: 16.67 %
  • 40-49: 0.0 %
  • 50-59: 41.67 %
  • 60+: 37.5 %

What are other drugs people take besides Aciphex? *

  1. Compazine: 18 people, 64.29%
  2. Aredia: 18 people, 64.29%
  3. Synthroid: 14 people, 50.00%
  4. Zometa: 14 people, 50.00%
  5. Neurontin: 11 people, 39.29%
  6. Effexor: 11 people, 39.29%
  7. Dexamethasone: 11 people, 39.29%
  8. Zoloft: 11 people, 39.29%
  9. Nexium: 10 people, 35.71%
  10. Ambien: 10 people, 35.71%

What are other side effects people have besides Osteolysis? *

  1. Stress And Anxiety: 24 people, 85.71%
  2. Osteonecrosis Of Jaw (death of bone of jaw): 24 people, 85.71%
  3. Pain: 23 people, 82.14%
  4. Pain In Jaw: 21 people, 75.00%
  5. Depression: 15 people, 53.57%
  6. Headache (pain in head): 14 people, 50.00%
  7. Bone Disorder: 14 people, 50.00%
  8. Rib Fracture: 13 people, 46.43%
  9. Oral Disorder (mouth disease): 13 people, 46.43%
  10. Decreased Interest: 13 people, 46.43%

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 11 people, 39.29%
  2. Metastases To Bone (cancer spreads to bone): 7 people, 25.00%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 25.00%
  4. High Blood Pressure: 7 people, 25.00%
  5. Hypercalcaemia (elevated calcium (ca+) level in the blood): 5 people, 17.86%
  6. Depression: 5 people, 17.86%
  7. Breast Cancer Metastatic: 4 people, 14.29%
  8. Osteoporosis (bones weak and more likely to break): 3 people, 10.71%
  9. High Blood Cholesterol: 2 people, 7.14%
  10. Prostate Cancer: 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and have Osteolysis?

- Check whether Osteolysis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aciphex:

Osteolysis treatments and more:

How severe was Osteolysis and when was it recovered:

Expand to all the drugs that have ingredients of rabeprazole sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aciphex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteolysis:

Browse all the conditions that are associated with Osteolysis:

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium (the active ingredients of Aciphex) and Aciphex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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