Aciphex and Systemic lupus erythematosus - a phase IV clinical study of FDA data

Summary:

Systemic lupus erythematosus is reported as a side effect among people who take Aciphex (rabeprazole sodium), especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years also take Protonix, and have Pain.

The phase IV clinical study analyzes which people have Systemic lupus erythematosus when taking Aciphex. It is created by eHealthMe based on reports of 24,594 people who have side effects when taking Aciphex from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Systemic lupus erythematosus?

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue) is found to be associated with 1,087 drugs and 1,645 conditions by eHealthMe. Check the latest studies of Systemic lupus erythematosus.

On Jul, 31, 2026

24,594 people reported to have side effects when taking Aciphex.
Among them, 78 people (0.32%) have Systemic lupus erythematosus.

Could Aciphex cause Systemic lupus erythematosus?

Among these 78 people:

How long have people been on Aciphex when they have Systemic lupus erythematosus? *

What is the gender of people who have Systemic lupus erythematosus when taking Aciphex? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Systemic lupus erythematosus when taking Aciphex? *

What are other drugs people take besides Aciphex? *

What are other side effects people have besides Systemic lupus erythematosus? *

Dyspnea (difficult or laboured breathing): 17 people, 21.79%
Joint Pain: 17 people, 21.79%
Headache (pain in head): 16 people, 20.51%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 15 people, 19.23%
Fatigue (feeling of tiredness): 14 people, 17.95%
Sleep Apnea Syndrome: 14 people, 17.95%
Nausea (feeling of having an urge to vomit): 14 people, 17.95%
Chest Pain: 14 people, 17.95%
Sinusitis (inflammation of sinus): 12 people, 15.38%
Back Pain: 12 people, 15.38%

What are the existing conditions these people have? *

Pain: 15 people, 19.23%
Joint Pain: 10 people, 12.82%
Stable Angina (a constant chest pain): 8 people, 10.26%
Irritable Bowel Syndrome: 8 people, 10.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 8.97%
Diabetes: 7 people, 8.97%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 7 people, 8.97%
General Symptom: 7 people, 8.97%
Laryngitis (inflammation of the larynx): 7 people, 8.97%
Acne (skin problems that cause pimples): 7 people, 8.97%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and have Systemic lupus erythematosus?

- Check whether Systemic lupus erythematosus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aciphex:

Aciphex (25,301 reports)

Browse all side effects of Aciphex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic lupus erythematosus:

Systemic lupus erythematosus (1,087 drugs)

Browse all the conditions that are associated with Systemic lupus erythematosus:

Systemic lupus erythematosus (1,645 conditions)

Related publications that referenced our studies

Hania A, "Pyoderma Gangrenosum in a Patient With Systemic Lupus Erythematosus: Case Report", Journal of Medical Cases, 2014 Aug .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
Hania A, "Pyoderma Gangrenosum in a Patient With Systemic Lupus Erythematosus: Case Report", Journal of Medical Cases, 2014 Aug .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium (the active ingredients of Aciphex) and Aciphex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.