Acth and Aseptic necrosis - a phase IV clinical study of FDA data

Summary:

Aseptic necrosis is reported as a side effect among people who take Acth (corticotropin), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Aseptic necrosis when taking Acth. It is created by eHealthMe based on reports of 5,384 people who have side effects when taking Acth from the FDA, and is updated regularly.

What is Acth?

Acth has active ingredients of corticotropin. eHealthMe is studying from 5,402 Acth users. Check the latest studies of Acth.

What is Aseptic necrosis?

Aseptic necrosis (the death of bone tissue due to a lack of blood supply) is found to be associated with 1,347 drugs and 1,696 conditions by eHealthMe. Check the latest studies of Aseptic necrosis.

On Aug, 10, 2026

5,384 people reported to have side effects when taking Acth.
Among them, 13 people (0.24%) have Aseptic necrosis.

Among these 13 people:

How long have people been on Acth when they have Aseptic necrosis? *

What is the gender of people who have Aseptic necrosis when taking Acth? *

female: 50 %
male: 50 %

What is the age of people who have Aseptic necrosis when taking Acth? *

What are other drugs people take besides Acth? *

What are other side effects people have besides Aseptic necrosis? *

Drug Ineffective: 8 people, 61.54%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 53.85%
Hoarseness Or Changing Voice: 7 people, 53.85%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 53.85%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 7 people, 53.85%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 7 people, 53.85%
Movement - Uncoordinated: 7 people, 53.85%
Quality Of Life Decreased: 1 person, 7.69%
Oedema Peripheral (superficial swelling): 1 person, 7.69%
Muscle Spasms (muscle contraction): 1 person, 7.69%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 53.85%
Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 3 people, 23.08%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 2 people, 15.38%
Pain: 1 person, 7.69%
Optic Neuritis (optic nerve inflammation): 1 person, 7.69%
Focal Segmental Glomerulosclerosis (scar tissue that forms in parts of the kidney called glomeruli): 1 person, 7.69%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Acth and have Aseptic necrosis?

- Check whether Aseptic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acth:

Acth (5,402 reports)

Aseptic necrosis treatments and more:

Aseptic necrosis (59,829 reports)

Browse all side effects of Acth:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aseptic necrosis:

Aseptic necrosis (1,347 drugs)

Browse all the conditions that are associated with Aseptic necrosis:

Aseptic necrosis (1,696 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on corticotropin (the active ingredients of Acth) and Acth (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.