Gilenya and Flector drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Gilenya (fingolimod) and Flector (diclofenac epolamine). Common drug interactions include fall among females and amnesia among males.
The phase IV clinical study analyzes what interactions people have when they take Gilenya and Flector. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.
What is Gilenya?
Gilenya has active ingredients of fingolimod. It is often used in multiple sclerosis. eHealthMe is studying from 111,893 Gilenya users. Check the latest studies of Gilenya.
What is Flector?
Flector has active ingredients of diclofenac epolamine. It is often used in pain. eHealthMe is studying from 5,112 Flector users. Check the latest studies of Flector.
26 people who take Gilenya and Flector together, and have interactions are studied.

What are the common drug interactions of Gilenya and Flector, by gender? *:
female:
- Fall
- Fatigue (feeling of tiredness)
- Headache (pain in head)
- Balance disorder
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Hypoaesthesia (reduced sense of touch or sensation)
- Vision blurred
- Visual impairment
- Asthenia (weakness)
- Hypertension (high blood pressure)
male:
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Anxiety
- Hypoaesthesia (reduced sense of touch or sensation)
- Hypokinesia (decreased bodily movement)
- Memory impairment
- Micturition urgency (urgency to pass the urine)
- Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
- Muscular weakness (muscle weakness)
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Subdural haematoma (blood collects between the skull and the surface of the brain)
What are the common drug interactions of Gilenya and Flector, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Contusion (a type of hematoma of tissue in which capillaries)
- Fall
- Headache (pain in head)
- Fatigue (feeling of tiredness)
- Pyrexia (fever)
- Urinary incontinence (inability to control the flow of urine and involuntary urination)
30-39:
- Alanine aminotransferase increased
- Arthralgia (joint pain)
- Blood cholesterol increased
- Dermatitis allergic (inflammation of the skin due allergic reaction)
- Encephalitis (inflammation of the brain)
- Face oedema (swelling of face)
- Fatigue (feeling of tiredness)
- Headache (pain in head)
- Hemiparesis (weakness on one side of the body)
- Hypoaesthesia (reduced sense of touch or sensation)
40-49:
- Headache (pain in head)
- Asthenia (weakness)
- Diarrhoea
- Drug ineffective
- Hypertension (high blood pressure)
- Muscle spasms (muscle contraction)
- Cerebral disorder (brain disease)
- Dry skin
- Fatigue (feeling of tiredness)
- Flushing (the warm, red condition of human skin)
50-59:
- Fall
- Balance disorder
- Hypoaesthesia (reduced sense of touch or sensation)
- Pain in extremity
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Visual impairment
- Fatigue (feeling of tiredness)
- Memory impairment
- Urinary incontinence (inability to control the flow of urine and involuntary urination)
- Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
60+:
- Balance disorder
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Depression
- Eye oedema (swelling or thickening of the macula, the area of the retina responsible for central vision)
- Eye pain
- Fatigue (feeling of tiredness)
- Headache (pain in head)
- Heart rate irregular
- Hypertension (high blood pressure)
- Hypoaesthesia (reduced sense of touch or sensation)
What are the existing conditions these people have? *
- Gait Disturbance: 3 people, 11.54%
- Stress And Anxiety: 2 people, 7.69%
- Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 7.69%
- Muscle Spasms (muscle contraction): 2 people, 7.69%
- Migraine (headache): 2 people, 7.69%
- Agitation (state of anxiety or nervous excitement): 2 people, 7.69%
* Approximation only. Some reports may have incomplete information.
Do you take Gilenya and Flector?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Gilenya and Flector:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Gilenya:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Flector:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Gilenya and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Flector and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
- Alroughani R, "Fingolimod-associated amenorrhea: a report of three cases", Multiple Sclerosis Journal, 2014 Jan .
- Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
- Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
- Alroughani R, "Fingolimod-associated amenorrhea: a report of three cases", Multiple Sclerosis Journal, 2014 Jan .
- Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on fingolimod and diclofenac epolamine (the active ingredients of Gilenya and Flector, respectively), and Gilenya and Flector (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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