Acthar and Heart attack - a phase IV clinical study of FDA data

Summary:

Heart attack is reported as a side effect among people who take Acthar (corticotropin), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Plavix, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Heart attack when taking Acthar. It is created by eHealthMe based on reports of 4,932 people who have side effects when taking Acthar from the FDA, and is updated regularly.

What is Acthar?

Acthar has active ingredients of corticotropin. eHealthMe is studying from 4,948 Acthar users. Check the latest studies of Acthar.

What is Heart attack?

Heart attack is found to be associated with 2,512 drugs and 3,289 conditions by eHealthMe. Check the latest studies of Heart attack.



On Mar, 30, 2026

4,932 people reported to have side effects when taking Acthar.
Among them, 39 people (0.79%) have Heart attack.

Could Acthar cause Heart attack?

Among these 39 people:

How long have people been on Acthar when they have Heart attack? *

  • < 1 month: 50.0 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 16.67 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Heart attack when taking Acthar? *

  • female: 44.74 %
  • male: 55.26 %

What is the age of people who have Heart attack when taking Acthar? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 4 %
  • 50-59: 52 %
  • 60+: 44 %

What are other drugs people take besides Acthar? *

  1. Plavix: 4 people, 10.26%
  2. Lipitor: 3 people, 7.69%
  3. Zantac: 2 people, 5.13%
  4. Lyrica: 2 people, 5.13%
  5. Xanax: 2 people, 5.13%
  6. Hydrocodone: 2 people, 5.13%
  7. Metformin: 2 people, 5.13%
  8. Vitamin D: 2 people, 5.13%
  9. Synthroid: 2 people, 5.13%
  10. Lasix: 2 people, 5.13%

What are other side effects people have besides Heart attack? *

  1. Fall: 4 people, 10.26%
  2. Acute Kidney Failure: 4 people, 10.26%
  3. Drug Ineffective: 4 people, 10.26%
  4. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 7.69%
  5. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 3 people, 7.69%
  6. Pneumonia: 3 people, 7.69%
  7. Injection Site Bruising: 2 people, 5.13%
  8. Injection Site Discoloration: 2 people, 5.13%
  9. Injection Site Pain: 2 people, 5.13%
  10. Hypotension (abnormally low blood pressure): 2 people, 5.13%

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 15.38%
  2. Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 5 people, 12.82%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.26%
  4. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 7.69%
  5. Glomerulonephritis Membranous (nephritis with inflammation of the capillary loops in the renal glomeruli): 3 people, 7.69%
  6. Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 2 people, 5.13%
  7. Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 2 people, 5.13%
  8. Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 2 people, 5.13%
  9. Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 2 people, 5.13%
  10. Myopathy (a muscular disease in which the muscle fibres do not function): 1 person, 2.56%

* Approximation only. Some reports may have incomplete information.

Do you take Acthar and have Heart attack?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acthar:

Heart attack treatments and more:

How severe was Heart attack and when was it recovered:

Expand to all the drugs that have ingredients of corticotropin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acthar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart attack:

Browse all the conditions that are associated with Heart attack:


How the study uses the data?

The study uses data from the FDA. It is based on corticotropin (the active ingredients of Acthar) and Acthar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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