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Acthar and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Acthar (corticotropin), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Ampyra, and have Gait disturbance.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Acthar. It is created by eHealthMe based on reports of 4,932 people who have side effects when taking Acthar from the FDA, and is updated regularly.

What is Acthar?

Acthar has active ingredients of corticotropin. eHealthMe is studying from 4,948 Acthar users. Check the latest studies of Acthar.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,084 drugs and 1,366 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

4,932 people reported to have side effects when taking Acthar.
Among them, 63 people (1.28%) have Multiple sclerosis.

Could Acthar cause Multiple sclerosis?

Among these 63 people:

How long have people been on Acthar when they have Multiple sclerosis? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Multiple sclerosis when taking Acthar? *

  • female: 82.76 %
  • male: 17.24 %

What is the age of people who have Multiple sclerosis when taking Acthar? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 5.41 %
  • 30-39: 5.41 %
  • 40-49: 18.92 %
  • 50-59: 40.54 %
  • 60+: 29.73 %

What are other drugs people take besides Acthar? *

  1. Ampyra: 19 people, 30.16%
  2. Vitamin D: 10 people, 15.87%
  3. Xeljanz: 8 people, 12.70%
  4. Humira: 8 people, 12.70%
  5. Orencia: 8 people, 12.70%
  6. Tysabri: 8 people, 12.70%
  7. Tecfidera: 7 people, 11.11%
  8. Rebif: 6 people, 9.52%
  9. Gilenya: 5 people, 7.94%
  10. Wellbutrin: 5 people, 7.94%

What are other side effects people have besides Multiple sclerosis? *

  1. Fall: 21 people, 33.33%
  2. Drug Ineffective: 16 people, 25.40%
  3. Weakness: 14 people, 22.22%
  4. Gait Disturbance: 12 people, 19.05%
  5. Fatigue (feeling of tiredness): 11 people, 17.46%
  6. Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 15.87%
  7. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 12.70%
  8. Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 8 people, 12.70%
  9. Hoarseness Or Changing Voice: 7 people, 11.11%
  10. Hypoaesthesia (reduced sense of touch or sensation): 7 people, 11.11%

What are the existing conditions these people have? *

  1. Gait Disturbance: 10 people, 15.87%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 12.70%
  3. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 7.94%
  4. Weakness: 4 people, 6.35%
  5. Fatigue (feeling of tiredness): 4 people, 6.35%
  6. Neuralgia (pain in one or more nerves): 4 people, 6.35%
  7. Nausea (feeling of having an urge to vomit): 4 people, 6.35%
  8. Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 6.35%
  9. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 3 people, 4.76%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Acthar and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acthar:

Multiple sclerosis treatments and more:

How severe was Multiple sclerosis and when was it recovered:

Expand to all the drugs that have ingredients of corticotropin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acthar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Browse all the conditions that are associated with Multiple sclerosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on corticotropin (the active ingredients of Acthar) and Acthar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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