Actifed and Stroke - a phase IV clinical study of FDA data

Summary:

Stroke is reported as a side effect among people who take Actifed (pseudoephedrine hydrochloride; triprolidine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Prilosec, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Stroke when taking Actifed. It is created by eHealthMe based on reports of 991 people who have side effects when taking Actifed from the FDA, and is updated regularly.

What is Actifed?

Actifed has active ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride. It is often used in allergies. eHealthMe is studying from 1,091 Actifed users. Check the latest studies of Actifed.

What is Stroke?

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) is found to be associated with 2,457 drugs and 3,004 conditions by eHealthMe. Check the latest studies of Stroke.

On Aug, 01, 2025

991 people reported to have side effects when taking Actifed.
Among them, 28 people (2.83%) have Stroke.

Among these 28 people:

How long have people been on Actifed when they have Stroke? *

What is the gender of people who have Stroke when taking Actifed? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Stroke when taking Actifed? *

What are other drugs people take besides Actifed? *

What are other side effects people have besides Stroke? *

Depression: 10 people, 35.71%
Stress And Anxiety: 10 people, 35.71%
Chest Pain: 9 people, 32.14%
Hepatic Failure (liver failure): 8 people, 28.57%
Fall: 8 people, 28.57%
Splenomegaly (enlargement of spleen): 8 people, 28.57%
Headache (pain in head): 7 people, 25.00%
Gallstones (stone formation by bile component): 7 people, 25.00%
Muscle Aches (muscle pain): 7 people, 25.00%
Myopathy (a muscular disease in which the muscle fibres do not function): 7 people, 25.00%

What are the existing conditions these people have? *

High Blood Cholesterol: 6 people, 21.43%
Nasopharyngitis (inflammation of the nasopharynx): 5 people, 17.86%
Oedema (fluid collection in tissue): 3 people, 10.71%
Wound: 2 people, 7.14%
Swelling: 2 people, 7.14%
Sleep Disorder: 2 people, 7.14%
High Blood Pressure: 2 people, 7.14%
Pain: 1 person, 3.57%
Menopause (end of monthly cycles in women): 1 person, 3.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Actifed and have Stroke?

- Check whether Stroke is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actifed:

Actifed (1,091 reports)

Stroke treatments and more:

Stroke (334,630 reports)

How severe was Stroke and when was it recovered:

Stroke in Actifed

Browse all side effects of Actifed:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Stroke:

Stroke (2,457 drugs)

Browse all the conditions that are associated with Stroke:

Stroke (3,004 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pseudoephedrine hydrochloride; triprolidine hydrochloride (the active ingredients of Actifed) and Actifed (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.