Actonel and Initial insomnia - a phase IV clinical study of FDA data

Summary:

Initial insomnia is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 60+ old, also take Synthroid, and have High blood pressure.

The phase IV clinical study analyzes which people have Initial insomnia when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Initial insomnia?

Initial insomnia (feeling of inadequate or poor-quality sleep) is found to be associated with 806 drugs and 676 conditions by eHealthMe. Check the latest studies of Initial insomnia.

On Sep, 23, 2025

28,929 people reported to have side effects when taking Actonel.
Among them, 27 people (0.09%) have Initial insomnia.

Among these 27 people:

What is the gender of people who have Initial insomnia when taking Actonel? *

female: 92 %
male: 8 %

What is the age of people who have Initial insomnia when taking Actonel? *

What are other drugs people take besides Actonel? *

What are other side effects people have besides Initial insomnia? *

Skin Blushing/flushing (a sudden reddening of the face, neck): 13 people, 48.15%
Diarrhea: 12 people, 44.44%
Weakness: 10 people, 37.04%
Nausea (feeling of having an urge to vomit): 10 people, 37.04%
Pain In Extremity: 9 people, 33.33%
Insomnia (sleeplessness): 9 people, 33.33%
Peripheral Swelling: 8 people, 29.63%
Tremor (trembling or shaking movements in one or more parts of your body): 8 people, 29.63%
High Blood Cholesterol: 7 people, 25.93%
Ill-Defined Disorder: 7 people, 25.93%

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 29.63%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 7 people, 25.93%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 22.22%
Pain In Extremity: 5 people, 18.52%
High Blood Cholesterol: 5 people, 18.52%
Bladder Disorder: 4 people, 14.81%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 11.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 11.11%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 11.11%
Insomnia (sleeplessness): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Initial insomnia?

- Check whether Initial insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Actonel (29,369 reports)

Initial insomnia treatments and more:

Initial insomnia (12,139 reports)

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Initial insomnia:

Initial insomnia (806 drugs)

Browse all the conditions that are associated with Initial insomnia:

Initial insomnia (676 conditions)

Drugs similar to Actonel and Initial insomnia :

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.