Actos and Bile duct obstruction - a phase IV clinical study of FDA data

Summary:

Bile duct obstruction is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Glucophage, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Bile duct obstruction when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Bile duct obstruction?

Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder) is found to be associated with 463 drugs and 625 conditions by eHealthMe. Check the latest studies of Bile duct obstruction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

49,087 people reported to have side effects when taking Actos.
Among them, 49 people (0.1%) have Bile duct obstruction.

Could Actos cause Bile duct obstruction?

Among these 49 people:

How long have people been on Actos when they have Bile duct obstruction? *

What is the gender of people who have Bile duct obstruction when taking Actos? *

female: 51.06 %
male: 48.94 %

What is the age of people who have Bile duct obstruction when taking Actos? *

What are other drugs people take besides Actos? *

What are other side effects people have besides Bile duct obstruction? *

Liver Function Tests Nos Abnormal: 13 people, 26.53%
Gallstones (stone formation by bile component): 12 people, 24.49%
Pancreatic Carcinoma (pancreatic cancer): 11 people, 22.45%
Blood Bilirubin Increased: 11 people, 22.45%
Fall: 10 people, 20.41%
Stress And Anxiety: 8 people, 16.33%
Fever: 8 people, 16.33%
Hepatic Steatosis (fatty liver disease): 8 people, 16.33%
Pancreatitis (inflammation of pancreas): 8 people, 16.33%
Weakness: 8 people, 16.33%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 6.12%
High Blood Pressure: 2 people, 4.08%
Weight Decreased: 1 person, 2.04%
Pancreatic Carcinoma (pancreatic cancer): 1 person, 2.04%
Lymphoma (cancer that begins in immune system cells): 1 person, 2.04%
High Blood Cholesterol: 1 person, 2.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 2.04%
Depression: 1 person, 2.04%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 2.04%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Bile duct obstruction?

- Check whether Bile duct obstruction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actos:

Actos (49,754 reports)

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bile duct obstruction:

Bile duct obstruction (463 drugs)

Browse all the conditions that are associated with Bile duct obstruction:

Bile duct obstruction (625 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.