Actos and Bone - broken - a phase IV clinical study of FDA data
Summary:
Bone - broken is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Lyrica, and have Osteoporosis.
The phase IV clinical study analyzes which people have Bone - broken when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.
What is Actos?
Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.
What is Bone - broken?
Bone - broken is found to be associated with 2,115 drugs and 1,493 conditions by eHealthMe. Check the latest studies of Bone - broken.
49,087 people reported to have side effects when taking Actos.
Among them, 86 people (0.18%) have Bone - broken.

Among these 86 people:
How long have people been on Actos when they have Bone - broken? *
What is the gender of people who have Bone - broken when taking Actos? *
What is the age of people who have Bone - broken when taking Actos? *
What are other drugs people take besides Actos? *
What are other side effects people have besides Bone - broken? *
What are the existing conditions these people have? *
* Approximation only. Some reports may have incomplete information.
Do you take Actos and have Bone - broken?
- Check whether Bone - broken is associated with a drug or a condition
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Related studies:
Effectiveness of, long term effects of, and alternative drugs to Actos:
- Actos (49,754 reports)
Bone - broken treatments and more:
- Bone - broken (35,552 reports)
How severe was Bone - broken and when was it recovered:
Expand to all the drugs that have ingredients of pioglitazone hydrochloride:
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Common Actos side effects:
- Actos side effect: Bladder cancer (9,566 reports)
- Actos side effect: Blood glucose increased (4,027 reports)
- Actos side effect: Weight increased (2,220 reports)
- Actos side effect: Fatigue (feeling of tiredness) (1,902 reports)
- Actos side effect: Nausea and vomiting (1,802 reports)
- Actos side effect: Dyspnea (difficult or laboured breathing) (1,801 reports)
- Actos side effect: Dizziness (1,710 reports)
- Actos side effect: Oedema peripheral (superficial swelling) (1,672 reports)
- Actos side effect: Cardiac failure congestive (1,619 reports)
- Actos side effect: Heart attack (1,514 reports)
- Actos side effect: Blood glucose decreased (1,443 reports)
- Actos side effect: Drug ineffective (1,370 reports)
- Actos side effect: Fall (1,305 reports)
- Actos side effect: Malaise (a feeling of general discomfort or uneasiness) (1,135 reports)
- Actos side effect: Anaemia (lack of blood) (1,098 reports)
- Actos side effect: Rashes (redness) (1,000 reports)
- Actos side effect: Oedema (fluid collection in tissue) (966 reports)
- Actos side effect: Chronic kidney disease (832 reports)
- Actos side effect: Pain in extremity (802 reports)
- Actos side effect: Diabetes mellitus inadequate control (785 reports)
- Actos side effect: Abdominal pain (778 reports)
- Actos side effect: Dehydration (dryness resulting from the removal of water) (740 reports)
- Actos side effect: Tremor (trembling or shaking movements in one or more parts of your body) (732 reports)
- Actos side effect: Insomnia (sleeplessness) (711 reports)
- Actos side effect: Bladder transitional cell carcinoma (types of bladder cancer) (703 reports)
- Actos side effect: Pancreatitis (inflammation of pancreas) (630 reports)
- Actos side effect: Muscle aches (muscle pain) (616 reports)
- Actos side effect: Glycosylated haemoglobin increased (598 reports)
- Actos side effect: Abdominal distension (533 reports)
- Actos side effect: Hypoaesthesia (reduced sense of touch or sensation) (523 reports)
- Actos side effect: Alanine aminotransferase increased (516 reports)
- Actos side effect: Fluid retention (an abnormal accumulation of fluid in the blood) (499 reports)
- Actos side effect: Injury (497 reports)
- Actos side effect: Injection site pain (477 reports)
- Actos side effect: Hyperhidrosis (abnormally increased sweating) (475 reports)
- Actos side effect: Aspartate aminotransferase increased (466 reports)
- Actos side effect: Renal impairment (severely reduced kidney function) (459 reports)
- Actos side effect: Gait disturbance (445 reports)
- Actos side effect: Cardiac disorder (440 reports)
- Actos side effect: Blood creatinine increased (435 reports)
- Actos side effect: Haematuria (presence of blood in urine) (434 reports)
- Actos side effect: Gastrointestinal haemorrhage (bleeding gastrointestinal tract) (432 reports)
- Actos side effect: Haemoglobin decreased (431 reports)
- Actos side effect: Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect) (428 reports)
- Actos side effect: Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight) (424 reports)
- Actos side effect: Confusional state (405 reports)
- Actos side effect: Sepsis (a severe blood infection that can lead to organ failure and death) (392 reports)
- Actos side effect: Emotional distress (389 reports)
- Actos side effect: Infection (386 reports)
- Actos side effect: Head injury (379 reports)
- Actos side effect: Swelling (378 reports)
- Actos side effect: Drug hypersensitivity (373 reports)
- Actos side effect: Injection site haemorrhage (bleeding from injection site) (372 reports)
- Actos side effect: Neuropathy peripheral (surface nerve damage) (363 reports)
- Actos side effect: Sinusitis (inflammation of sinus) (356 reports)
- Actos side effect: Bronchitis (inflammation of the mucous membrane in the bronchial tubes) (352 reports)
- Actos side effect: Cellulitis (infection under the skin) (345 reports)
- Actos side effect: Nasopharyngitis (inflammation of the nasopharynx) (339 reports)
- Actos side effect: Injection site bruising (330 reports)
- Actos side effect: Heart rate increased (329 reports)
- Actos side effect: Renal injury (kidney injury) (305 reports)
- Actos side effect: Flatulence (flatus expelled through the anus) (299 reports)
- Actos side effect: Acute myocardial infarction (acute heart attack) (297 reports)
- Actos side effect: Enlarged heart (296 reports)
- Actos side effect: Visual acuity reduced (reduced clearness of vision) (285 reports)
- Actos side effect: Hair loss (281 reports)
- Actos side effect: Blood bilirubin increased (277 reports)
- Actos side effect: Renal disorder (kidney disease) (276 reports)
- Actos side effect: Cataract (clouding of the lens inside the eye) (275 reports)
- Actos side effect: Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down) (270 reports)
- Actos side effect: Osteonecrosis of jaw (death of bone of jaw) (269 reports)
- Actos side effect: Dyspnea exertional (267 reports)
- Actos side effect: White blood cell count decreased (266 reports)
- Actos side effect: Nervousness (257 reports)
- Actos side effect: Taste - impaired (256 reports)
- Actos side effect: Hypersensitivity (247 reports)
- Actos side effect: Blood glucose fluctuation (240 reports)
- Actos side effect: Osteoporosis (bones weak and more likely to break) (238 reports)
- Actos side effect: Anhedonia (inability to experience pleasure from activities usually found enjoyable) (236 reports)
- Actos side effect: Ascites (accumulation of fluid in the abdominal cavity) (231 reports)
- Actos side effect: Balance disorder (230 reports)
- Actos side effect: Blood creatine phosphokinase increased (229 reports)
- Actos side effect: Oedema lower limb (fluid collection in tissue of lower leg) (228 reports)
- Actos side effect: Osteomyelitis (infection of bone) (227 reports)
- Actos side effect: Peripheral swelling (225 reports)
- Actos side effect: Dry mouth (224 reports)
- Actos side effect: Hyperlipidaemia (presence of excess lipids in the blood) (219 reports)
- Actos side effect: Gastritis (inflammation of stomach) (217 reports)
- Actos side effect: Depressed level of consciousness (215 reports)
- Actos side effect: Rectal haemorrhage (bleeding from anus) (209 reports)
- Actos side effect: Prostate cancer (207 reports)
- Actos side effect: Coronary artery occlusion (complete obstruction of blood flow in a coronary artery) (202 reports)
- Actos side effect: White blood cell count increased (199 reports)
- Actos side effect: Hepatic failure (liver failure) (196 reports)
- Actos side effect: Feeling jittery (195 reports)
- Actos side effect: Speech impairment (adult) (inability to speak (adult)) (192 reports)
- Actos side effect: Mitral valve incompetence (inefficient heart valve) (187 reports)
- Actos side effect: Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) (186 reports)
- Actos side effect: Neck pain (185 reports)
- Actos side effect: Pulmonary congestion (congestion in the lungs) (183 reports)
- Actos side effect: Diabetic retinopathy (damage to the retina caused by complications of diabetes) (182 reports)
- Actos side effect: Swelling face (181 reports)
- Actos side effect: Bone disorder (179 reports)
- Actos side effect: Cardio-respiratory arrest (sudden dysfunction of heart and lungs) (178 reports)
- Actos side effect: Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) (176 reports)
- Actos side effect: Liver disorder (liver diseases) (173 reports)
- Actos side effect: Face oedema (swelling of face) (171 reports)
- Actos side effect: Bradycardia (abnormally slow heart action) (170 reports)
- Actos side effect: Gastrointestinal disorder (functional problems of gastrointestinal tract) (167 reports)
- Actos side effect: Hepatitis (inflammation of the liver) (163 reports)
- Actos side effect: Burning sensation (162 reports)
- Actos side effect: Spinal osteoarthritis (joint cartilage loss in spine) (161 reports)
- Actos side effect: Bladder cancer recurrent (160 reports)
- Actos side effect: Blood alkaline phosphatase increased (159 reports)
- Actos side effect: Feeling cold (155 reports)
- Actos side effect: Urinary retention (the inability to completely or partially empty the bladder) (151 reports)
- Actos side effect: Blood urine present (150 reports)
- Actos side effect: Mobility decreased (ability to move is reduced) (149 reports)
- Actos side effect: Cardiomyopathy (weakening of the heart muscle) (148 reports)
- Actos side effect: Abasia (inability to walk) (147 reports)
- Actos side effect: Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure) (146 reports)
- Actos side effect: Tooth disorder (tooth disease) (144 reports)
- Actos side effect: Intervertebral disc protrusion (spinal disc protrusion) (142 reports)
- Actos side effect: Oropharyngeal pain (140 reports)
- Actos side effect: Angina unstable (chest pain due to ischemia of the heart muscle- unstable) (139 reports)
- Actos side effect: Speech disorder (138 reports)
- Actos side effect: Rash pruritic (redness with itching) (135 reports)
- Actos side effect: Femur fracture (134 reports)
- Actos side effect: Disease progression (132 reports)
- Actos side effect: Stomatitis (inflammation of mucous membrane of mouth) (131 reports)
- Actos side effect: Skin discoloration (128 reports)
- Actos side effect: Renal cyst (kidney cyst) (127 reports)
- Actos side effect: Injection site erythema (redness at injection site) (126 reports)
- Actos side effect: Hypophagia (reduced food intake) (125 reports)
- Actos side effect: Rib fracture (123 reports)
- Actos side effect: Tooth extraction (122 reports)
- Actos side effect: Bone pain (120 reports)
- Actos side effect: Multi-organ failure (multisystem organ failure) (119 reports)
- Actos side effect: Upper limb fracture (116 reports)
- Actos side effect: Pharyngitis (inflammation of the pharynx, causing a sore throat) (113 reports)
- Actos side effect: Ankle fracture (112 reports)
- Actos side effect: Metastatic carcinoma of the bladder (cancer types can spread to the bladder from other place) (111 reports)
- Actos side effect: Musculoskeletal chest pain (pain in chest muscle or nerve or bones) (108 reports)
- Actos side effect: Visual disturbance (107 reports)
- Actos side effect: Injection site pruritus (severe itching at injection site) (106 reports)
- Actos side effect: C-reactive protein increased (105 reports)
- Actos side effect: Panic disorder (103 reports)
- Actos side effect: Presyncope (102 reports)
- Actos side effect: Disturbance in attention (101 reports)
Browse all side effects of Actos:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon drugs associated with Bone - broken:
- Fosamax (5,456 reports)
- Truvada (4,388 reports)
- Viread (2,741 reports)
- Atripla (2,508 reports)
- Alendronate sodium (2,046 reports)
- Prolia (1,737 reports)
- Prednisone (1,681 reports)
- Methotrexate (1,567 reports)
- Forteo (1,346 reports)
- Aspirin (1,196 reports)
- Boniva (1,059 reports)
- Actonel (1,058 reports)
- Stribild (998 reports)
- Enbrel (957 reports)
- Biktarvy (943 reports)
- Vitamins (867 reports)
- Calcium (822 reports)
- Descovy (782 reports)
- Genvoya (741 reports)
- Synthroid (722 reports)
- Humira (713 reports)
- Omeprazole (687 reports)
- Celebrex (668 reports)
- Pantoprazole (649 reports)
- Revlimid (622 reports)
- Tramadol (601 reports)
- Xeljanz (563 reports)
- Nexium (560 reports)
- Gabapentin (559 reports)
- Zometa (556 reports)
- Amlodipine (535 reports)
- Ibu (525 reports)
- Ibuprofen (522 reports)
- Lipitor (519 reports)
- Lisinopril (513 reports)
- Actemra (490 reports)
- Simvastatin (480 reports)
- Lyrica (468 reports)
- Tylenol (453 reports)
- Prednisolone (446 reports)
- Metformin (429 reports)
- Orencia (416 reports)
- Plaquenil (406 reports)
- Zide (405 reports)
- Furosemide (398 reports)
- Prilosec (396 reports)
- Hydrochlorothiazide (392 reports)
- Folic acid (386 reports)
- Arava (359 reports)
- Premarin (357 reports)
- Lasix (356 reports)
- Simponi (355 reports)
- Albuterol (347 reports)
- Loraz (346 reports)
- Ramipril (340 reports)
- Lorazepam (338 reports)
- Leflunomide (337 reports)
- Magnesium (336 reports)
- Oxycodone (335 reports)
- Evista (329 reports)
- Remicade (325 reports)
- Fosamax plus d (313 reports)
- Risedronate sodium (312 reports)
- Oxycontin (311 reports)
- Ambien (309 reports)
- Levothyroxine sodium (308 reports)
- Protonix (305 reports)
- Zoloft (303 reports)
- Singulair (301 reports)
- Reclast (296 reports)
- Morphine (292 reports)
- Neurontin (288 reports)
- Aredia (287 reports)
- Cymbalta (286 reports)
- Acetaminophen (281 reports)
- Coumadin (273 reports)
- Dexamethasone (272 reports)
- Avandia (269 reports)
- Acetylsalicylic acid (266 reports)
- Cimzia (257 reports)
- Atenolol (256 reports)
- Zolpidem (253 reports)
- Crestor (246 reports)
- Diazepam (243 reports)
- Prevacid (241 reports)
- Vioxx (235 reports)
- Levaquin (232 reports)
- Plavix (231 reports)
- Accutane (229 reports)
- Eliquis (225 reports)
- Diphen (224 reports)
- Alprazolam (219 reports)
- Vicodin (218 reports)
- Flonase (217 reports)
- Paxil (214 reports)
- Mirtazapine (212 reports)
- Sertraline (211 reports)
- Sulfasalazine (210 reports)
- Pregabalin (209 reports)
- Amoxicillin (207 reports)
- Lopurin (205 reports)
- Percocet (204 reports)
- Zyrtec (203 reports)
- Spiriva (195 reports)
- Losartan (191 reports)
- Spironolactone (190 reports)
- Benadryl (189 reports)
- Meloxicam (187 reports)
- Vitamin b12 (185 reports)
- Xolair (184 reports)
- Vitamin c (181 reports)
- Lansoprazole (180 reports)
- Lantus (179 reports)
- Centrum (176 reports)
- Zofran (172 reports)
- Ativan (171 reports)
- Zantac (170 reports)
- Baclofen (169 reports)
- Wellbutrin (166 reports)
- Ranitidine (165 reports)
- Zoledronic acid (162 reports)
- Lexapro (161 reports)
- Prozac (160 reports)
- Bactrim (158 reports)
- Seroquel (152 reports)
- Dilaudid (151 reports)
- Advair diskus 100/50 (149 reports)
- Sandostatin (148 reports)
- Paracetamol (145 reports)
- Entresto (144 reports)
- Letrozole (143 reports)
- Taxotere (142 reports)
- Carvedilol (141 reports)
- Advair hfa (140 reports)
- Celecoxib (139 reports)
- Cephalexin (138 reports)
- Pantoprazole sodium (137 reports)
- Femara (135 reports)
- Omega-3 marine triglycerides (134 reports)
- Miacalcin (131 reports)
- Lovenox (130 reports)
- Ondansetron (129 reports)
- Famotidine (128 reports)
- Amlodipine besylate (127 reports)
- Norvir (126 reports)
- Hydrocodone bitartrate and acetaminophen (125 reports)
- Methylprednisolone (124 reports)
- Hydroxychloroquine sulfate (123 reports)
- Claritin (122 reports)
- Clopidogrel (121 reports)
- Zyprexa (119 reports)
- Abilify (117 reports)
- Xeloda (116 reports)
- Xgeva (115 reports)
- Paroxetine (113 reports)
- Vitamin e (111 reports)
- Ocrevus (110 reports)
- Metoclopramide (109 reports)
- Humalog (108 reports)
- Avastin (107 reports)
- Ergocalciferol (106 reports)
- Levetiracetam (104 reports)
- Clonidine (103 reports)
- Anastrozole (102 reports)
- Metoprolol succinate (101 reports)
Browse all the drugs that are associated with Bone - broken:
- Bone - broken (2,115 drugs)
Common conditions associated with Bone - broken:
- Osteoporosis: 6,502 reports
- Hiv infection: 5,345 reports
- Ra: 2,623 reports
- Arthritis - rheumatoid: 2,563 reports
- Osteopenia: 2,269 reports
- Hbp: 979 reports
- High blood pressure: 973 reports
- Plasma cell dyscrasia: 817 reports
- Pain: 741 reports
- Hypnosis and pain: 736 reports
- Depression: 501 reports
- Antidepressant therapy: 500 reports
- Depression aggravated: 490 reports
- Asthma: 477 reports
- Exercise-induced asthma: 476 reports
- Blood cholesterol increased: 453 reports
- Multiple sclerosis: 433 reports
- Diabetes: 432 reports
- Dm: 430 reports
- Osteoporosis postmenopausal: 422 reports
- Gerds: 414 reports
- Acupuncture and pain: 398 reports
- Cancer - breast: 377 reports
- Hypothyroid: 367 reports
- Parkinson's disease: 339 reports
- Arthritis: 321 reports
- Lipid profile: 301 reports
- Reduce cholesterol: 283 reports
- Glucose test: 281 reports
- Type 2 diabetes: 276 reports
- Type 2 diabetes mellitus: 271 reports
- Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 266 reports
- Psoriasis: 265 reports
- Crohn's disease: 263 reports
- Psoriatic arthropathy aggravated: 231 reports
- Preventive health care: 226 reports
- Metastases to bone: 216 reports
- Breast cancer metastatic: 211 reports
- Atrial fibrillation: 193 reports
- Sleeping difficulty: 178 reports
- Insomnia exacerbated: 175 reports
- Hypersensitivity: 167 reports
- Sleep disorder therapy: 166 reports
- Hrt: 164 reports
- Prostate cancer: 162 reports
- Non-small cell lung cancer: 152 reports
- Primary pulmonary hypertension: 149 reports
- Chronic obstructive pulmonary disease: 147 reports
- Chronic obstructive airway disease: 145 reports
- Schizophrenia: 135 reports
- Thyroid disorder: 134 reports
- Thyroid diseases: 133 reports
- Constipation: 126 reports
- Blood pressure abnormal: 122 reports
- Narcolepsy: 121 reports
- Stool softener needs: 120 reports
- Rheumatoid spondylitis: 111 reports
- Fibrositis: 110 reports
- Hepatitis b: 108 reports
- Acne: 105 reports
- Epilepsy: 103 reports
- Acne vulgaris: 101 reports
Browse all the conditions that are associated with Bone - broken:
- Bone - broken (1,493 conditions)
Drugs similar to Actos and Bone - broken :
- Byetta and Bone - broken
- Glimepiride and Bone - broken
- Glipizide and Bone - broken
- Glucophage and Bone - broken
- Glyburide and Bone - broken
- Humalog and Bone - broken
- Insulin and Bone - broken
- Janumet and Bone - broken
- Januvia and Bone - broken
- Lantus and Bone - broken
- Levemir and Bone - broken
- Metformin and Bone - broken
- Metformin hydrochloride and Bone - broken
- Novolog and Bone - broken
- Victoza and Bone - broken
How the study uses the data?
The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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