Actos and Left ventricular failure - a phase IV clinical study of FDA data

Summary:

Left ventricular failure is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Lasix, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Left ventricular failure when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Left ventricular failure?

Left ventricular failure (left ventricle fails to contract forcefully) is found to be associated with 590 drugs and 666 conditions by eHealthMe. Check the latest studies of Left ventricular failure.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

49,087 people reported to have side effects when taking Actos.
Among them, 25 people (0.05%) have Left ventricular failure.

Could Actos cause Left ventricular failure?

Among these 25 people:

How long have people been on Actos when they have Left ventricular failure? *

What is the gender of people who have Left ventricular failure when taking Actos? *

female: 60 %
male: 40 %

What is the age of people who have Left ventricular failure when taking Actos? *

What are other drugs people take besides Actos? *

What are other side effects people have besides Left ventricular failure? *

Weight Increased: 11 people, 44.00%
Cardiac Failure Congestive: 9 people, 36.00%
Mitral Valve Incompetence (inefficient heart valve): 5 people, 20.00%
Ejection Fraction Abnormal (abnormality in percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat): 4 people, 16.00%
Pleural Effusion (water on the lungs): 4 people, 16.00%
Heart Attack: 3 people, 12.00%
Respiratory Distress (difficulty in breathing): 3 people, 12.00%
Aortic Valve Incompetence: 3 people, 12.00%
Chest Pain: 3 people, 12.00%
Cough: 3 people, 12.00%

What are the existing conditions these people have? *

Hypogonadism Male (male testes produce little or no sex hormone): 1 person, 4.00%
Heart Disease: 1 person, 4.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Left ventricular failure?

- Check whether Left ventricular failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actos:

Actos (49,754 reports)

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Left ventricular failure:

Left ventricular failure (590 drugs)

Browse all the conditions that are associated with Left ventricular failure:

Left ventricular failure (666 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.