Actos and Spinal fusion surgery - a phase IV clinical study of FDA data

Summary:

Spinal fusion surgery is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are male, 50-59 old, also take Prilosec, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Spinal fusion surgery when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Spinal fusion surgery?

Spinal fusion surgery is found to be associated with 493 drugs and 421 conditions by eHealthMe. Check the latest studies of Spinal fusion surgery.

On Aug, 02, 2026

49,087 people reported to have side effects when taking Actos.
Among them, 20 people (0.04%) have Spinal fusion surgery.

Could Actos cause Spinal fusion surgery?

Among these 20 people:

What is the gender of people who have Spinal fusion surgery when taking Actos? *

female: 40 %
male: 60 %

What is the age of people who have Spinal fusion surgery when taking Actos? *

What are other drugs people take besides Actos? *

What are other side effects people have besides Spinal fusion surgery? *

Stress And Anxiety: 12 people, 60.00%
High Blood Pressure: 11 people, 55.00%
Heart Attack: 10 people, 50.00%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 10 people, 50.00%
Urination - Excessive Volume: 10 people, 50.00%
Atelectasis (partial or complete collapse of the lung): 10 people, 50.00%
Back Pain: 10 people, 50.00%
Pleural Effusion (water on the lungs): 10 people, 50.00%
Faecal Incontinence (a lack of control over passing stool): 10 people, 50.00%
Multiple Myeloma (cancer of the plasma cells): 10 people, 50.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 10 people, 50.00%
Stress And Anxiety: 3 people, 15.00%
Parkinson's Disease: 3 people, 15.00%
Pain In Jaw: 3 people, 15.00%
Muscle Spasms (muscle contraction): 3 people, 15.00%
Left Ventricular Dysfunction: 3 people, 15.00%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 15.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.00%
Depression: 3 people, 15.00%
Abnormal Dreams: 3 people, 15.00%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Spinal fusion surgery?

- Check whether Spinal fusion surgery is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actos:

Actos (49,754 reports)

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spinal fusion surgery:

Spinal fusion surgery (493 drugs)

Browse all the conditions that are associated with Spinal fusion surgery:

Spinal fusion surgery (421 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.