Acyclovir and Neurological decompensation - a phase IV clinical study of FDA data

Summary:

Neurological decompensation is reported as a side effect among people who take Acyclovir (acyclovir), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Methylprednisolone, and have Acute lymphocytic leukemia (all).

The phase IV clinical study analyzes which people have Neurological decompensation when taking Acyclovir. It is created by eHealthMe based on reports of 53,484 people who have side effects when taking Acyclovir from the FDA, and is updated regularly.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

What is Neurological decompensation?

Neurological decompensation (inability of brain to maintain proper function) is found to be associated with 255 drugs and 451 conditions by eHealthMe. Check the latest studies of Neurological decompensation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

53,484 people reported to have side effects when taking Acyclovir.
Among them, 18 people (0.03%) have Neurological decompensation.

Could Acyclovir cause Neurological decompensation?

Among these 18 people:

How long have people been on Acyclovir when they have Neurological decompensation? *

What is the gender of people who have Neurological decompensation when taking Acyclovir? *

female: 5.88 %
male: 94.12 %

What is the age of people who have Neurological decompensation when taking Acyclovir? *

What are other drugs people take besides Acyclovir? *

What are other side effects people have besides Neurological decompensation? *

Drug Ineffective: 6 people, 33.33%
Confusional State: 6 people, 33.33%
Haemorrhage (bleeding): 5 people, 27.78%
Acute Hepatic Failure: 5 people, 27.78%
Eyes/pupils Different Size: 5 people, 27.78%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 5 people, 27.78%
Stupor (lack of critical cognitive function and level of consciousness): 4 people, 22.22%
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 4 people, 22.22%
Agitation (state of anxiety or nervous excitement): 4 people, 22.22%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 22.22%

What are the existing conditions these people have? *

Confusional State: 4 people, 22.22%
Agitation (state of anxiety or nervous excitement): 4 people, 22.22%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 22.22%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 3 people, 16.67%
Interstitial Lung Disease: 3 people, 16.67%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 1 person, 5.56%
Malignant Lymphoid Neoplasm (malignant growth or tumour caused by abnormal and uncontrolled cell division in lymph node): 1 person, 5.56%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 5.56%
Encephalitis (inflammation of the brain): 1 person, 5.56%
Cytomegalovirus Infection: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Acyclovir and have Neurological decompensation?

- Check whether Neurological decompensation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acyclovir:

Acyclovir (54,961 reports)

Browse all side effects of Acyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Neurological decompensation:

Neurological decompensation (255 drugs)

Browse all the conditions that are associated with Neurological decompensation:

Neurological decompensation (451 conditions)

Related publications that referenced our studies

Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on acyclovir (the active ingredients of Acyclovir) and Acyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.