Adderall and Dependence - a phase IV clinical study of FDA data

Summary:

Dependence is reported as a side effect among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate), especially for people who are male, 30-39 old, have been taking the drug for 5 - 10 years also take Xanax, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Dependence when taking Adderall. It is created by eHealthMe based on reports of 50,493 people who have side effects when taking Adderall from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,226 Adderall users. Check the latest studies of Adderall.

What is Dependence?

Dependence is found to be associated with 411 drugs and 453 conditions by eHealthMe. Check the latest studies of Dependence.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

50,493 people reported to have side effects when taking Adderall.
Among them, 35 people (0.07%) have Dependence.

Among these 35 people:

How long have people been on Adderall when they have Dependence? *

What is the gender of people who have Dependence when taking Adderall? *

female: 44.12 %
male: 55.88 %

What is the age of people who have Dependence when taking Adderall? *

What are other drugs people take besides Adderall? *

Ambien: 7 people, 20.00%
Xanax: 7 people, 20.00%
Hydrocodone Bitartrate And Acetaminophen: 5 people, 14.29%
Seroquel: 5 people, 14.29%
Abilify: 4 people, 11.43%
Norco: 4 people, 11.43%
Ativan: 4 people, 11.43%
Cymbalta: 4 people, 11.43%
Plavix: 3 people, 8.57%
Naltrexone: 3 people, 8.57%

What are other side effects people have besides Dependence? *

Anger: 6 people, 17.14%
Fall: 6 people, 17.14%
Insomnia (sleeplessness): 6 people, 17.14%
Irritability: 5 people, 14.29%
Psychiatric Symptom: 5 people, 14.29%
Impaired Work Ability: 5 people, 14.29%
Alcoholism (problems with alcohol): 5 people, 14.29%
Fatigue (feeling of tiredness): 5 people, 14.29%
Stress And Anxiety: 5 people, 14.29%
Drowsiness: 5 people, 14.29%

What are the existing conditions these people have? *

Stress And Anxiety: 8 people, 22.86%
Insomnia (sleeplessness): 7 people, 20.00%
Pain: 6 people, 17.14%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 4 people, 11.43%
Bipolar Disorder (mood disorder): 3 people, 8.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 5.71%
Sleep Disorder: 1 person, 2.86%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 2.86%
Post-Traumatic Stress Disorder: 1 person, 2.86%
Pain In Extremity: 1 person, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Adderall and have Dependence?

- Check whether Dependence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adderall:

Adderall (64,226 reports)

Dependence treatments and more:

Dependence (56,849 reports)

How severe was Dependence and when was it recovered:

Dependence in Adderall

Expand to all the drugs that have ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate:

Dependence and drugs with ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (57 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Adderall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dependence:

Dependence (411 drugs)

Browse all the conditions that are associated with Dependence:

Dependence (453 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (the active ingredients of Adderall) and Adderall (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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