Adderall and Difficulty falling asleep - a phase IV clinical study of FDA data

Summary:

Difficulty falling asleep is reported as a side effect among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Xyrem, and have Cataplexy.

The phase IV clinical study analyzes which people have Difficulty falling asleep when taking Adderall. It is created by eHealthMe based on reports of 50,493 people who have side effects when taking Adderall from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,211 Adderall users. Check the latest studies of Adderall.

What is Difficulty falling asleep?

Difficulty falling asleep is found to be associated with 4,651 drugs and 5,371 conditions by eHealthMe. Check the latest studies of Difficulty falling asleep.



On Nov, 27, 2025

50,493 people reported to have side effects when taking Adderall.
Among them, 2,125 people (4.21%) have Difficulty falling asleep.

Could Adderall cause Difficulty falling asleep?

Among these 2,125 people:

How long have people been on Adderall when they have Difficulty falling asleep? *

  • < 1 month: 31.71 %
  • 1 - 6 months: 16.46 %
  • 6 - 12 months: 10.98 %
  • 1 - 2 years: 15.24 %
  • 2 - 5 years: 14.63 %
  • 5 - 10 years: 7.32 %
  • 10+ years: 3.66 %

What is the gender of people who have Difficulty falling asleep when taking Adderall? *

  • female: 67.4 %
  • male: 32.6 %

What is the age of people who have Difficulty falling asleep when taking Adderall? *

  • 0-1: 0.08 %
  • 2-9: 4.0 %
  • 10-19: 9.21 %
  • 20-29: 15.26 %
  • 30-39: 20.24 %
  • 40-49: 23.87 %
  • 50-59: 17.82 %
  • 60+: 9.52 %

What are other drugs people take besides Adderall? *

  1. Xyrem: 642 people, 30.21%
  2. Xanax: 229 people, 10.78%
  3. Wellbutrin: 191 people, 8.99%
  4. Cymbalta: 171 people, 8.05%
  5. Klonopin: 165 people, 7.76%
  6. Vitamin D3: 148 people, 6.96%
  7. Vyvanse: 145 people, 6.82%
  8. Lexapro: 138 people, 6.49%
  9. Seroquel: 137 people, 6.45%
  10. Nuvigil: 130 people, 6.12%

What are other side effects people have besides Difficulty falling asleep? *

  1. Stress And Anxiety: 502 people, 23.62%
  2. Fatigue (feeling of tiredness): 476 people, 22.40%
  3. Nausea (feeling of having an urge to vomit): 344 people, 16.19%
  4. Drug Ineffective: 331 people, 15.58%
  5. Headache (pain in head): 324 people, 15.25%
  6. Feeling Abnormal: 291 people, 13.69%
  7. Pain: 243 people, 11.44%
  8. Drowsiness: 236 people, 11.11%
  9. Memory Loss: 221 people, 10.40%
  10. Dizziness: 217 people, 10.21%

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 351 people, 16.52%
  2. Stress And Anxiety: 163 people, 7.67%
  3. Drowsiness: 140 people, 6.59%
  4. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 127 people, 5.98%
  5. Pain: 123 people, 5.79%
  6. Bipolar Disorder (mood disorder): 97 people, 4.56%
  7. Sleep Disorder: 89 people, 4.19%
  8. High Blood Pressure: 61 people, 2.87%
  9. High Blood Cholesterol: 49 people, 2.31%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 42 people, 1.98%

* Approximation only. Some reports may have incomplete information.

Do you take Adderall and have Difficulty falling asleep?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adderall:

Difficulty falling asleep treatments and more:

How severe was Difficulty falling asleep and when was it recovered:

Expand to all the drugs that have ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Adderall side effects:

Browse all side effects of Adderall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Difficulty falling asleep:

Browse all the drugs that are associated with Difficulty falling asleep:

Common conditions associated with Difficulty falling asleep:

Browse all the conditions that are associated with Difficulty falling asleep:

Drugs similar to Adderall and Difficulty falling asleep :


How the study uses the data?

The study uses data from the FDA. It is based on amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (the active ingredients of Adderall) and Adderall (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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