Adderall and Pyrosis - a phase IV clinical study of FDA data

Summary:

Pyrosis is reported as a side effect among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Xyrem, and have Cataplexy.

The phase IV clinical study analyzes which people have Pyrosis when taking Adderall. It is created by eHealthMe based on reports of 50,493 people who have side effects when taking Adderall from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,213 Adderall users. Check the latest studies of Adderall.

What is Pyrosis?

Pyrosis (painful burning sensation in the chest caused by gastroesophageal reflux) is found to be associated with 3,568 drugs and 3,464 conditions by eHealthMe. Check the latest studies of Pyrosis.

On Nov, 23, 2025

50,493 people reported to have side effects when taking Adderall.
Among them, 574 people (1.14%) have Pyrosis.

Among these 574 people:

* Approximation only. Some reports may have incomplete information.

Do you take Adderall and have Pyrosis?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adderall:

Adderall (64,213 reports)

Pyrosis treatments and more:

Pyrosis (445,757 reports)

How severe was Pyrosis and when was it recovered:

Pyrosis in Adderall

Expand to all the drugs that have ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate:

Pyrosis and drugs with ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (693 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Adderall side effects:

Adderall side effect: Drug ineffective (5,223 reports)
Adderall side effect: Nausea (feeling of having an urge to vomit) (3,692 reports)

Browse all side effects of Adderall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Pyrosis:

Browse all the drugs that are associated with Pyrosis:

Pyrosis (3,568 drugs)

Common conditions associated with Pyrosis:

Hypertension aggravated: 8,809 reports
Blood pressure increased: 8,796 reports
Gerds: 8,087 reports
Heartburn - chronic: 7,618 reports
Osteoporosis: 6,424 reports
Thin bones: 6,141 reports
Reflux esophagitis: 5,786 reports
Pain exacerbated: 5,547 reports
Hypnosis and pain: 5,525 reports
Gastro-oesophageal reflux disease: 5,263 reports

Browse all the conditions that are associated with Pyrosis:

Pyrosis (3,464 conditions)

Drugs similar to Adderall and Pyrosis :

How the study uses the data?

The study uses data from the FDA. It is based on amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (the active ingredients of Adderall) and Adderall (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.