Advil pm and Indigestion - a phase IV clinical study of FDA data

Summary:

Indigestion is reported as a side effect among people who take Advil pm (diphenhydramine hydrochloride; ibuprofen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Carisoprodol, and have Depression.

The phase IV clinical study analyzes which people have Indigestion when taking Advil pm. It is created by eHealthMe based on reports of 1,146 people who have side effects when taking Advil pm from the FDA, and is updated regularly.

What is Advil pm?

Advil pm has active ingredients of diphenhydramine hydrochloride; ibuprofen. It is often used in insomnia. eHealthMe is studying from 1,445 Advil pm users. Check the latest studies of Advil pm.

What is Indigestion?

Indigestion is found to be associated with 2,419 drugs and 3,412 conditions by eHealthMe. Check the latest studies of Indigestion.

On Jul, 28, 2026

1,146 people reported to have side effects when taking Advil pm.
Among them, 12 people (1.05%) have Indigestion.

Among these 12 people:

How long have people been on Advil pm when they have Indigestion? *

What is the gender of people who have Indigestion when taking Advil pm? *

female: 58.33 %
male: 41.67 %

What is the age of people who have Indigestion when taking Advil pm? *

What are other drugs people take besides Advil pm? *

What are other side effects people have besides Indigestion? *

Weight Decreased: 2 people, 16.67%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%
Drug Ineffective: 2 people, 16.67%
Dry Mouth: 2 people, 16.67%
Taste - Impaired: 2 people, 16.67%
Fatigue (feeling of tiredness): 1 person, 8.33%
Back Pain: 1 person, 8.33%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 1 person, 8.33%
Cardiac Disorder: 1 person, 8.33%

What are the existing conditions these people have? *

Sleep Disorder: 2 people, 16.67%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 16.67%
Depression: 2 people, 16.67%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 8.33%
Pain In Extremity: 1 person, 8.33%
Muscle Spasms (muscle contraction): 1 person, 8.33%
Muscle Aches (muscle pain): 1 person, 8.33%
Leg Pain: 1 person, 8.33%
Joint Pain: 1 person, 8.33%
Hyperchlorhydria (gastric acid levels are higher in stomach): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Advil pm and have Indigestion?

- Check whether Indigestion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Advil pm:

Advil pm (1,445 reports)

Indigestion treatments and more:

Indigestion (445,029 reports)

How severe was Indigestion and when was it recovered:

Indigestion in Advil pm

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride; ibuprofen:

Indigestion and drugs with ingredients of diphenhydramine hydrochloride; ibuprofen

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Advil pm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Indigestion:

Indigestion (2,419 drugs)

Browse all the conditions that are associated with Indigestion:

Indigestion (3,412 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride; ibuprofen (the active ingredients of Advil pm) and Advil pm (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.