Advil and Extrapyramidal disorder - a phase IV clinical study of FDA data

Summary:

Extrapyramidal disorder is reported as a side effect among people who take Advil (ibuprofen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Metoclopramide, and have Indigestion.

The phase IV clinical study analyzes which people have Extrapyramidal disorder when taking Advil. It is created by eHealthMe based on reports of 60,378 people who have side effects when taking Advil from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,534 Advil users. Check the latest studies of Advil.

What is Extrapyramidal disorder?

Extrapyramidal disorder (involuntary muscle spasms in the face and neck) is found to be associated with 813 drugs and 960 conditions by eHealthMe. Check the latest studies of Extrapyramidal disorder.

On Aug, 08, 2026

60,378 people reported to have side effects when taking Advil.
Among them, 11 people (0.02%) have Extrapyramidal disorder.

Could Advil cause Extrapyramidal disorder?

Among these 11 people:

How long have people been on Advil when they have Extrapyramidal disorder? *

What is the gender of people who have Extrapyramidal disorder when taking Advil? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Extrapyramidal disorder when taking Advil? *

What are other drugs people take besides Advil? *

What are other side effects people have besides Extrapyramidal disorder? *

Tardive Dyskinesia (a disorder that involves involuntary movements): 6 people, 54.55%
Stress And Anxiety: 5 people, 45.45%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 4 people, 36.36%
Multiple Injuries: 3 people, 27.27%
Dyskinesia (abnormality or impairment of voluntary movement): 3 people, 27.27%
Activities Of Daily Living Impaired: 3 people, 27.27%
Deformity (disfigurement): 3 people, 27.27%
Emotional Distress: 3 people, 27.27%
Cholecystitis Chronic (long lasting infection of gallbladder): 3 people, 27.27%
Biliary Dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi): 3 people, 27.27%

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 2 people, 18.18%
Birth Control: 2 people, 18.18%
Premenstrual Syndrome: 2 people, 18.18%
Multiple Allergies (allergy to multiple agents): 2 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
Indigestion: 2 people, 18.18%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 9.09%
Clonic Convulsion (long lasting seizure): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Advil and have Extrapyramidal disorder?

- Check whether Extrapyramidal disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Advil:

Advil (62,534 reports)

Browse all side effects of Advil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Extrapyramidal disorder:

Extrapyramidal disorder (813 drugs)

Browse all the conditions that are associated with Extrapyramidal disorder:

Extrapyramidal disorder (960 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Advil) and Advil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.