Advil and Hepatic encephalopathy - a phase IV clinical study of FDA data

Summary:

Hepatic encephalopathy is reported as a side effect among people who take Advil (ibuprofen), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Prevacid, and have Otitis media.

The phase IV clinical study analyzes which people have Hepatic encephalopathy when taking Advil. It is created by eHealthMe based on reports of 60,378 people who have side effects when taking Advil from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Hepatic encephalopathy?

Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure) is found to be associated with 914 drugs and 1,259 conditions by eHealthMe. Check the latest studies of Hepatic encephalopathy.

On Jul, 21, 2026

60,378 people reported to have side effects when taking Advil.
Among them, 36 people (0.06%) have Hepatic encephalopathy.

Could Advil cause Hepatic encephalopathy?

Among these 36 people:

How long have people been on Advil when they have Hepatic encephalopathy? *

What is the gender of people who have Hepatic encephalopathy when taking Advil? *

female: 45.71 %
male: 54.29 %

What is the age of people who have Hepatic encephalopathy when taking Advil? *

What are other drugs people take besides Advil? *

What are other side effects people have besides Hepatic encephalopathy? *

Acute Kidney Failure: 18 people, 50.00%
Hepatic Failure (liver failure): 15 people, 41.67%
Hepatic Necrosis (large portions of liver die off due to severe liver disease): 9 people, 25.00%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 8 people, 22.22%
Hypotension (abnormally low blood pressure): 8 people, 22.22%
General Physical Health Deterioration (weak health status): 7 people, 19.44%
Gait Disturbance: 7 people, 19.44%
Liver Function Tests Nos Abnormal: 7 people, 19.44%
Multi-Organ Failure (multisystem organ failure): 7 people, 19.44%
Nausea (feeling of having an urge to vomit): 6 people, 16.67%

What are the existing conditions these people have? *

Otitis Media (inflammation of the middle ear): 4 people, 11.11%
Rashes (redness): 2 people, 5.56%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 5.56%
Ear Pain: 2 people, 5.56%
Insomnia (sleeplessness): 2 people, 5.56%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 2.78%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 2.78%
Allergic Rhinitis: 1 person, 2.78%
Ascites (accumulation of fluid in the abdominal cavity): 1 person, 2.78%
Breast Cancer Metastatic: 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Advil and have Hepatic encephalopathy?

- Check whether Hepatic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Advil:

Advil (62,533 reports)

Browse all side effects of Advil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic encephalopathy:

Hepatic encephalopathy (914 drugs)

Browse all the conditions that are associated with Hepatic encephalopathy:

Hepatic encephalopathy (1,259 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Advil) and Advil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.