Advil and Lactic acidosis - a phase IV clinical study of FDA data

Summary:

Lactic acidosis is reported as a side effect among people who take Advil (ibuprofen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Glucophage, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Lactic acidosis when taking Advil. It is created by eHealthMe based on reports of 60,378 people who have side effects when taking Advil from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Lactic acidosis?

Lactic acidosis (low ph in body tissues) is found to be associated with 994 drugs and 1,277 conditions by eHealthMe. Check the latest studies of Lactic acidosis.

On Jul, 22, 2026

60,378 people reported to have side effects when taking Advil.
Among them, 29 people (0.05%) have Lactic acidosis.

Among these 29 people:

How long have people been on Advil when they have Lactic acidosis? *

What is the gender of people who have Lactic acidosis when taking Advil? *

female: 58.62 %
male: 41.38 %

What is the age of people who have Lactic acidosis when taking Advil? *

What are other drugs people take besides Advil? *

What are other side effects people have besides Lactic acidosis? *

Acute Kidney Failure: 11 people, 37.93%
Nausea And Vomiting: 6 people, 20.69%
Diarrhea: 5 people, 17.24%
Duodenal Ulcer Haemorrhage (bleeding duodenal ulcer): 4 people, 13.79%
Gastric Ulcer Haemorrhage (bleeding ulcer of stomach): 4 people, 13.79%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 4 people, 13.79%
General Physical Health Deterioration (weak health status): 3 people, 10.34%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 3 people, 10.34%
Melaena (the passage of black, tarry stools): 2 people, 6.90%
Encephalopathy (functioning of the brain is affected by some agent or condition): 2 people, 6.90%

What are the existing conditions these people have? *

Type 2 Diabetes: 4 people, 13.79%
Heart Attack: 3 people, 10.34%
Vitamin B12 Deficiency: 2 people, 6.90%
Migraine (headache): 2 people, 6.90%
Depression: 2 people, 6.90%
Sleep Apnea Syndrome: 2 people, 6.90%
Pancreatic Carcinoma (pancreatic cancer): 2 people, 6.90%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.90%
Constipation: 1 person, 3.45%
Diabetes: 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Advil and have Lactic acidosis?

- Check whether Lactic acidosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Advil:

Advil (62,533 reports)

Lactic acidosis treatments and more:

Lactic acidosis (34,314 reports)

Browse all side effects of Advil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lactic acidosis:

Lactic acidosis (994 drugs)

Browse all the conditions that are associated with Lactic acidosis:

Lactic acidosis (1,277 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Advil) and Advil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.