Afinitor and Ventricular dysfunction - a phase IV clinical study of FDA data

Summary:

Ventricular dysfunction is reported as a side effect among people who take Afinitor (everolimus), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Keflex, and have Metastatic renal cell carcinoma.

The phase IV clinical study analyzes which people have Ventricular dysfunction when taking Afinitor. It is created by eHealthMe based on reports of 41,609 people who have side effects when taking Afinitor from the FDA, and is updated regularly.

What is Afinitor?

Afinitor has active ingredients of everolimus. It is often used in breast cancer metastatic. eHealthMe is studying from 41,680 Afinitor users. Check the latest studies of Afinitor.

What is Ventricular dysfunction?

Ventricular dysfunction (heart dysfunction) is found to be associated with 551 drugs and 549 conditions by eHealthMe. Check the latest studies of Ventricular dysfunction.

On Oct, 25, 2025

41,609 people reported to have side effects when taking Afinitor.
Among them, 11 people (0.03%) have Ventricular dysfunction.

Could Afinitor cause Ventricular dysfunction?

Among these 11 people:

How long have people been on Afinitor when they have Ventricular dysfunction? *

What is the gender of people who have Ventricular dysfunction when taking Afinitor? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Ventricular dysfunction when taking Afinitor? *

What are other drugs people take besides Afinitor? *

Keflex: 3 people, 27.27%
Zometa: 1 person, 9.09%
Rebif: 1 person, 9.09%
Aromasin: 1 person, 9.09%
Actrapid: 1 person, 9.09%

What are other side effects people have besides Ventricular dysfunction? *

Dyspnea (difficult or laboured breathing): 6 people, 54.55%
Cardiomyopathy (weakening of the heart muscle): 5 people, 45.45%
Cardiac Enzymes Increased: 4 people, 36.36%
Electrocardiogram Abnormal: 4 people, 36.36%
Tricuspid Valve Incompetence (inefficient heart valve): 4 people, 36.36%
Left Ventricular Hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 4 people, 36.36%
Herpes Zoster: 3 people, 27.27%
Cardiac Failure: 3 people, 27.27%
Acute Kidney Failure: 3 people, 27.27%
General Physical Health Deterioration (weak health status): 2 people, 18.18%

What are the existing conditions these people have? *

Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 7 people, 63.64%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 45.45%
High Blood Pressure: 5 people, 45.45%
Localised Infection (infection at the single location): 3 people, 27.27%
Cardiac Failure Congestive: 2 people, 18.18%
Renal Cancer Metastatic (cancer of kidney spreads to other part): 1 person, 9.09%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 9.09%
Metastases To Bone (cancer spreads to bone): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Afinitor and have Ventricular dysfunction?

- Check whether Ventricular dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Afinitor:

Afinitor (41,680 reports)

Browse all side effects of Afinitor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ventricular dysfunction:

Ventricular dysfunction (551 drugs)

Browse all the conditions that are associated with Ventricular dysfunction:

Ventricular dysfunction (549 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on everolimus (the active ingredients of Afinitor) and Afinitor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.