Akineton and Hypernatraemia - a phase IV clinical study of FDA data

Summary:

Hypernatraemia is reported as a side effect among people who take Akineton (biperiden hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Norvasc, and have High blood pressure.

The phase IV clinical study analyzes which people have Hypernatraemia when taking Akineton. It is created by eHealthMe based on reports of 6,101 people who have side effects when taking Akineton from the FDA, and is updated regularly.

What is Akineton?

Akineton has active ingredients of biperiden hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 6,140 Akineton users. Check the latest studies of Akineton.

What is Hypernatraemia?

Hypernatraemia (an abnormally high plasma concentration of sodium ions) is found to be associated with 645 drugs and 807 conditions by eHealthMe. Check the latest studies of Hypernatraemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

6,101 people reported to have side effects when taking Akineton.
Among them, 25 people (0.41%) have Hypernatraemia.

Among these 25 people:

How long have people been on Akineton when they have Hypernatraemia? *

What is the gender of people who have Hypernatraemia when taking Akineton? *

female: 54.17 %
male: 45.83 %

What is the age of people who have Hypernatraemia when taking Akineton? *

What are other drugs people take besides Akineton? *

What are other side effects people have besides Hypernatraemia? *

Fever: 13 people, 52.00%
Blood Creatine Phosphokinase Increased: 11 people, 44.00%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 9 people, 36.00%
Monoparesis (one limb is very weak, but not completely paralyzed): 6 people, 24.00%
Pneumonia: 6 people, 24.00%
Agitation (state of anxiety or nervous excitement): 6 people, 24.00%
Dehydration (dryness resulting from the removal of water): 6 people, 24.00%
Hypokalemia (low potassium): 6 people, 24.00%
Consciousness - Decreased: 6 people, 24.00%
Anaemia (lack of blood): 6 people, 24.00%

What are the existing conditions these people have? *

Schizoaffective Disorder (a mental disorder characterized by disordered thought): 11 people, 44.00%
High Blood Pressure: 11 people, 44.00%
Bipolar Disorder (mood disorder): 7 people, 28.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 6 people, 24.00%
Procedural Pain: 6 people, 24.00%
Dyslipidaemia (abnormal amount of lipids): 6 people, 24.00%
Cardiac Failure: 6 people, 24.00%
Psychotic Disorder: 3 people, 12.00%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 3 people, 12.00%
Alcoholism (problems with alcohol): 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

Do you take Akineton and have Hypernatraemia?

- Check whether Hypernatraemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Akineton:

Akineton (6,140 reports)

Hypernatraemia treatments and more:

Hypernatraemia (6,339 reports)

Browse all side effects of Akineton:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypernatraemia:

Hypernatraemia (645 drugs)

Browse all the conditions that are associated with Hypernatraemia:

Hypernatraemia (807 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on biperiden hydrochloride (the active ingredients of Akineton) and Akineton (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.